Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial

doi:10.1017/S2045796020000384

IVPP-IR > 中科院古脊椎所（2000年以后）

	Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial
	Hung, Chung-Chieh 1,2; Lee, Chien-Hung 3,4,5; Ko, Albert Min-Shan 6; Lane, Hsien-Yuan 1,2,7; Lee, Chi-Pin 8; Ko, Ying-Chin 8
	2020
发表期刊	EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
ISSN	2045-7960
卷号	29 页码:10
通讯作者	Ko, Ying-Chin(ycko0406@gmail.com)
摘要	Aims More than one-half of betel-quid (BQ) chewers have betel-quid use disorder (BUD). However, no medication has been approved. We performed a randomised clinical trial to test the efficacy of taking escitalopram and moclobemide antidepressants on betel-quid chewing cessation (BQ-CC) treatment. Methods We enrolled 111 eligible male BUD patients. They were double-blinded, placebo-controlled and randomised into three treatment groups: escitalopram 10 mg/tab daily, moclobemide 150 mg/tab daily and placebo. Patients were followed-up every 2 weeks and the length of the trial was 8 weeks. The primary outcome was BQ-CC, defined as BUD patients who continuously stopped BQ use for > 6 weeks. The secondary outcomes were the frequency and amount of BQ intake, and two psychological rating scales. Several clinical adverse effects were measured during the 8-week treatment. Results Intention-to-treat analysis shows that after 8 weeks, two (5.4%), 13 (34.2%) and 12 (33.3%) of BUD patients continuously quit BQ chewing for > 6 weeks among placebo, escitalopram, moclobemide groups, respectively. The adjusted proportion ratio of BQ-CC was 6.3 (95% CI 1.5-26.1) and 6.8 (95% CI 1.6-28.0) for BUD patients who used escitalopram and moclobemide, respectively, as compared with those who used placebo. BUD patients with escitalopram and moclobemide treatments both exhibited a significantly lower frequency and amount of BQ intake at the 8th week than those with placebo. Conclusions Prescribing a fixed dose of moclobemide and escitalopram to BUD patients over 8 weeks demonstrated treatment benefits to BQ-CC. Given a relatively small sample, this study provides preliminary evidence and requires replication in larger trials.
关键词	Clinical drug studies common mental disorders epidemiology psychoactive substance use disorder randomised controlled trials
DOI	10.1017/S2045796020000384
关键词[WOS]	OBSESSIVE-COMPULSIVE SCALE ; PROTEIN MODIFICATION ; CHINESE VERSION ; ARECA NUT ; DEPENDENCE ; SUBSTRATE ; ESCITALOPRAM ; INVENTORY ; SEVERITY ; MEMORY
收录类别	SCI
语种	英语
资助项目	Taiwan Ministry of Health and Welfare Clinical Trial Center[MOHW109-TDU-B212-114004] ; China Medical University Hospital[DMR-106-098] ; China Medical University Hospital[DMR-108-094]
项目资助者	Taiwan Ministry of Health and Welfare Clinical Trial Center ; China Medical University Hospital
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000530304700001
出版者	CAMBRIDGE UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/17418
专题	中科院古脊椎所（2000年以后）
通讯作者	Ko, Ying-Chin
作者单位	1.China Med Univ, Grad Inst Clin Med Sci, Taichung, Taiwan 2.China Med Univ Hosp, Dept Psychiat, Taichung, Taiwan 3.Kaohsiung Med Univ, Dept Publ Hlth, Kaohsiung, Taiwan 4.Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan 5.Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan 6.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China 7.Asia Univ, Coll Med & Hlth Sci, Dept Psychol, Taichung, Taiwan 8.China Med Univ, China Med Univ Hosp, Environm Omics Dis Res Ctr, Taichung, Taiwan
推荐引用方式 GB/T 7714	Hung, Chung-Chieh,Lee, Chien-Hung,Ko, Albert Min-Shan,et al. Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial[J]. EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES,2020,29:10.
APA	Hung, Chung-Chieh,Lee, Chien-Hung,Ko, Albert Min-Shan,Lane, Hsien-Yuan,Lee, Chi-Pin,&Ko, Ying-Chin.(2020).Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial.EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES,29,10.
MLA	Hung, Chung-Chieh,et al."Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial".EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES 29(2020):10.