Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage

doi:10.1093/nsr/nwz206

IVPP-IR > 中科院古脊椎所（2000年以后）

	Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage
	Bailleul, Alida M.1,2; Zheng, Wenxia 3; Horner, John R.4; Hall, Brian K.5; Holliday, Casey M.6; Schweitzer, Mary H.3,7,8
	2020-04-01
发表期刊	NATIONAL SCIENCE REVIEW
ISSN	2095-5138
卷号	7 期号:4 页码:815-822
摘要	A histological ground-section from a duck-billed dinosaur nestling (Hypacrosaurus stebingeri) revealed microstructures morphologically consistent with nuclei and chromosomes in cells within calcified cartilage. We hypothesized that this exceptional cellular preservation extended to the molecular level and had molecular features in common with extant avian cartilage. Histochemical and immunological evidence supports in situ preservation of extracellular matrix components found in extant cartilage, including glycosaminoglycans and collagen type II. Furthermore, isolated Hypacrosaurus chondrocytes react positively with two DNA intercalating stains. Specific DNA staining is only observed inside the isolated cells, suggesting endogenous nuclear material survived fossilization. Our data support the hypothesis that calcified cartilage is preserved at the molecular level in this Mesozoic material, and suggest that remnants of once-living chondrocytes, including their DNA, may preserve for millions of years.
关键词	cartilage dinosaur nuclei chromosomes collagen II DNA markers
DOI	10.1093/nsr/nwz206
关键词[WOS]	SOFT-TISSUE ; CELL-DEATH ; GROWTH ; CHONDROCYTES ; BONE ; APOPTOSIS ; SEQUENCE ; VESSELS ; GENOME
收录类别	SCI
语种	英语
资助项目	National Science Foundation INSPIRE grant (Division of Earth Sciences)[EAR-1344198] ; American Association of Anatomists Short-Term Visiting Scholarship ; Chinese Academy of Sciences-President's International Fellowship Initiative (CAS-PIFI) ; NSF-IOS grant (Division of Integrative Organismal Systems)[1457319]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000537456300011
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/17534
专题	中科院古脊椎所（2000年以后）
通讯作者	Bailleul, Alida M.
作者单位	1.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 2.CAS Ctr Excellence Life & Paleoenvironm, Beijing 100044, Peoples R China 3.North Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA 4.Chapman Univ, Honors Program, Orange, CA 92866 USA 5.Dalhousie Univ, Dept Biol, Halifax, NS B3H 4R2, Canada 6.Univ Missouri, Dept Pathol & Anat Sci, Columbia, MO 65211 USA 7.North Uarolina Museum Nat Sci, Raleigh, NC 27601 USA 8.Lund Univ, Dept Geol, S-22362 Lund, Sweden
推荐引用方式 GB/T 7714	Bailleul, Alida M.,Zheng, Wenxia,Horner, John R.,et al. Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage[J]. NATIONAL SCIENCE REVIEW,2020,7(4):815-822.
APA	Bailleul, Alida M.,Zheng, Wenxia,Horner, John R.,Hall, Brian K.,Holliday, Casey M.,&Schweitzer, Mary H..(2020).Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage.NATIONAL SCIENCE REVIEW,7(4),815-822.
MLA	Bailleul, Alida M.,et al."Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage".NATIONAL SCIENCE REVIEW 7.4(2020):815-822.

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