Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia

doi:10.1371/journal.pone.0232520

IVPP-IR > 中科院古脊椎所（2000年以后）

	Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia
	Wang, Mei 1; Zhang, Chi 2
	2020-05-13
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	15 期号:5 页码:9
摘要	Early T-cell precursor (ETP) is the only subtype of acute T-cell lymphoblastic leukemia (T-ALL) listed in the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia. Patients with ETP tend to have worse disease outcomes. ETP is defined by a series of immune markers. The diagnosis of ETP status can be vague due to the limitation of the current measurement. In this study, we performed unsupervised clustering and supervised prediction to investigate whether a molecular biomarker can be used to identify the ETP status in order to stratify risk groups. We found that the ETP status can be predicted by the expression level of Lymphoid enhancer binding factor 1 (LEF1) with high accuracy (AUC of ROC = 0.957 and 0.933 in two T-ALL cohorts). The patients with ETP subtype have a lower level of LEF1 comparing to the those without ETP. We suggest that incorporating the biomarker LEF1 with traditional immune-phenotyping will improve the diagnosis of ETP.
DOI	10.1371/journal.pone.0232520
关键词[WOS]	WORLD-HEALTH-ORGANIZATION ; MYELOID NEOPLASMS ; CLASS DISCOVERY ; CLASSIFICATION ; REVISION ; MODELS ; TCF-1
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of Chinese Academy of Sciences[XDB26000000] ; 100 Young Talents Program of Chinese Academy of Sciences ; National Natural Science Foundation of China[81900155]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000537481000019
出版者	PUBLIC LIBRARY SCIENCE
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/17545
专题	中科院古脊椎所（2000年以后）
通讯作者	Wang, Mei
作者单位	1.Peking Univ, Sch Life Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Mei,Zhang, Chi. Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia[J]. PLOS ONE,2020,15(5):9.
APA	Wang, Mei,&Zhang, Chi.(2020).Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia.PLOS ONE,15(5),9.
MLA	Wang, Mei,et al."Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia".PLOS ONE 15.5(2020):9.

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