Genomic insights into population history and biological adaptation in Oceania

doi:10.1038/s41586-021-03236-5

IVPP-IR > 中科院古脊椎所（2000年以后）

	Genomic insights into population history and biological adaptation in Oceania
	Choin, Jeremy 1,2; Mendoza-Revilla, Javier 1; Arauna, Lara R.1; Cuadros-Espinoza, Sebastian 1,3; Cassar, Olivier 4; Larena, Maximilian 5; Ko, Albert Min-Shan 6; Harmant, Christine 1; Laurent, Romain 7; Verdu, Paul 7; Laval, Guillaume 1; Boland, Anne 8; Olaso, Robert 8; Deleuze, Jean-Francois 8; Valentin, Frederique 9; Ko, Ying-Chin 10; Jakobsson, Mattias 5,11; Gessain, Antoine 4; Excoffier, Laurent 12,13; Stoneking, Mark 14; Patin, Etienne 1; Quintana-Murci, Lluis 1,15
	2021-04-22
发表期刊	NATURE
ISSN	0028-0836
卷号	592 期号:7855 页码:583-+
通讯作者	Patin, Etienne(epatin@pasteur.fr) ; Quintana-Murci, Lluis(quintana@pasteur.fr)
摘要	The Pacific region is of major importance for addressing questions regarding human dispersals, interactions with archaic hominins and natural selection processes(1). However, the demographic and adaptive history of Oceanian populations remains largely uncharacterized. Here we report high-coverage genomes of 317 individuals from 20 populations from the Pacific region. We find that the ancestors of Papuan-related ('Near Oceanian') groups underwent a strong bottleneck before the settlement of the region, and separated around 20,000-40,000 years ago. We infer that the East Asian ancestors of Pacific populations may have diverged from Taiwanese Indigenous peoples before the Neolithic expansion, which is thought to have started from Taiwan around 5,000 years ago(2-4). Additionally, this dispersal was not followed by an immediate, single admixture event with Near Oceanian populations, but involved recurrent episodes of genetic interactions. Our analyses reveal marked differences in the proportion and nature of Denisovan heritage among Pacific groups, suggesting that independent interbreeding with highly structured archaic populations occurred. Furthermore, whereas introgression of Neanderthal genetic information facilitated the adaptation of modern humans related to multiple phenotypes (for example, metabolism, pigmentation and neuronal development), Denisovan introgression was primarily beneficial for immune-related functions. Finally, we report evidence of selective sweeps and polygenic adaptation associated with pathogen exposure and lipid metabolism in the Pacific region, increasing our understanding of the mechanisms of biological adaptation to island environments.
DOI	10.1038/s41586-021-03236-5
收录类别	SCI
语种	英语
资助项目	INCEPTION programme[ANR-16-CONV-0005] ; Ecole Doctorale FIRE-CRI-Programme Bettencourt ; Pasteur-Roux-Cantarini fellowship ; France Genomique National infrastructure - Investissements d'Avenir programme[ANR-10-INBS-09] ; Knut and Alice Wallenberg foundation ; Max Planck Society ; Institut Pasteur ; College de France ; CNRS ; Fondation Allianz-Institut de France ; French Government's Investissement d'Avenir programme, Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases'[ANR-10-LABX-62-IBEID] ; French Government's Investissement d'Avenir programme, Laboratoire d'Excellence 'Milieu Interieur'[ANR-10-LABX-69-01] ; regional office of the National Commission for Indigenous Peoples (NCIP)-Cagayan Valle ; provincial office of the National Commission for Indigenous Peoples (NCIP)-Cagayan Valley
项目资助者	INCEPTION programme ; Ecole Doctorale FIRE-CRI-Programme Bettencourt ; Pasteur-Roux-Cantarini fellowship ; France Genomique National infrastructure - Investissements d'Avenir programme ; Knut and Alice Wallenberg foundation ; Max Planck Society ; Institut Pasteur ; College de France ; CNRS ; Fondation Allianz-Institut de France ; French Government's Investissement d'Avenir programme, Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases' ; French Government's Investissement d'Avenir programme, Laboratoire d'Excellence 'Milieu Interieur' ; regional office of the National Commission for Indigenous Peoples (NCIP)-Cagayan Valle ; provincial office of the National Commission for Indigenous Peoples (NCIP)-Cagayan Valley
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000640159900001
出版者	NATURE RESEARCH
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/18488
专题	中科院古脊椎所（2000年以后）
通讯作者	Patin, Etienne; Quintana-Murci, Lluis
作者单位	1.Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France 2.Univ Paris Diderot, Sorbonne Paris Cite, Paris, France 3.Sorbonne Univ, Coll Doctoral, Paris, France 4.Inst Pasteur, CNRS, Oncogen Virus Epidemiol & Pathophysiol, UMR 3569, Paris, France 5.Uppsala Univ, Dept Organismal Biol, Human Evolut, Uppsala, Sweden 6.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China 7.Univ Paris, CNRS, UMR7206, Museum Natl Hist Nat, Paris, France 8.Univ Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, Inst Biol Francois Jacob, CEA, Evry, France 9.CNRS, UMR 7041, Maison Archeol & Ethnol, Nanterre, France 10.China Med Univ & Hosp, Environm Omics Dis Res Ctr, Taichung, Taiwan 11.Uppsala Univ, Sci Life Lab, Uppsala, Sweden 12.Univ Bern, Inst Ecol & Evolut, Bern, Switzerland 13.Swiss Inst Bioinformat, Lausanne, Switzerland 14.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, Leipzig, Germany 15.Coll France, Paris, France
推荐引用方式 GB/T 7714	Choin, Jeremy,Mendoza-Revilla, Javier,Arauna, Lara R.,et al. Genomic insights into population history and biological adaptation in Oceania[J]. NATURE,2021,592(7855):583-+.
APA	Choin, Jeremy.,Mendoza-Revilla, Javier.,Arauna, Lara R..,Cuadros-Espinoza, Sebastian.,Cassar, Olivier.,...&Quintana-Murci, Lluis.(2021).Genomic insights into population history and biological adaptation in Oceania.NATURE,592(7855),583-+.
MLA	Choin, Jeremy,et al."Genomic insights into population history and biological adaptation in Oceania".NATURE 592.7855(2021):583-+.