Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus)

doi:10.3389/fgene.2020.615926

IVPP-IR

	Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus)
	Kuang, Weimin 1; Hu, Jingyang 1; Wu, Hong 1; Fen, Xiaotian 2,3,4; Dai, Qingyan 2,3,4; Fu, Qiaomei2,3,4 ; Xiao, Wen 5; Frantz, Laurent 6,7; Roos, Christian 8; Nadler, Tilo ; Irwin, David M.9; Zhou, Linchun 10; Yang, Xu 11; Yu, Li 1
	2020-12-15
发表期刊	FRONTIERS IN GENETICS
卷号	11 期号:无页码:10
摘要	The snub-nosed monkey genus (Rhinopithecus) comprises five closely related species (R. avunculus, R. bieti, R. brelichi, R. roxellana, and R. strykeri). All are among the world's rarest and most endangered primates. However, the genomic impact associated with their population decline remains unknown. We analyzed population genomic data of all five snub-nosed monkey species to assess their genetic diversity, inbreeding level, and genetic load. For R. roxellana, R. bieti, and R. strykeri, population size is positively correlated with genetic diversity and negatively correlated with levels of inbreeding. Other species, however, which possess small population sizes, such as R. brelichi and R. avunculus, show high levels of genetic diversity and low levels of genomic inbreeding. Similarly, in the three populations of R. roxellana, the Shennongjia population, which possesses the lowest population size, displays a higher level of genetic diversity and lower level of genomic inbreeding. These findings suggest that although R. brelichi and R. avunculus and the Shennongjia population might be at risk, it possess significant genetic diversity and could thus help strengthen their long-term survival potential. Intriguingly, R. roxellana with large population size possess high genetic diversity and low level of genetic load, but they show the highest recent inbreeding level compared with the other snub-nosed monkeys. This suggests that, despite its large population size, R. roxellana has likely been experiencing recent inbreeding, which has not yet affected its mutational load and fitness. Analyses of homozygous-derived deleterious mutations identified in all snub-nosed monkey species indicate that these mutations are affecting immune, especially in smaller population sizes, indicating that the long-term consequences of inbreeding may be resulting in an overall reduction of immune capability in the snub-nosed monkeys, which could provide a dramatic effect on their long-term survival prospects. Altogether, our study provides valuable information concerning the genomic impact of population decline of the snub-nosed monkeys. We revealed multiple counterintuitive and unexpected patterns of genetic diversity in small and large population, which will be essential for conservation management of these endangered species.
关键词	snub-nosed monkeys population genomics genetic diversity inbreeding genetic load population decline
DOI	10.3389/fgene.2020.615926
关键词[WOS]	POPULATION DECLINE ; MITOCHONDRIAL-DNA ; GENOME ; CONSERVATION ; ROXELLANA ; PRIMATES ; PHYLOGEOGRAPHY ; HOMOZYGOSITY ; EXTINCTION ; FRAMEWORK
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31925006] ; Yunnan University's Research Innovation Fund for Graduate Students[2019z050] ; Academic Graduate Students Foundation of Yunnan Province
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000603613500001
出版者	FRONTIERS MEDIA SA
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/18726
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Yu, Li
作者单位	1.Yunnan Univ, Sch Life Sci, State Key Lab Conservat & Utilizat Bioresource Yu, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, CAS, IVPP, Beijing, Peoples R China 3.Chinese Acad Sci, Ctr Excellence Life & Paleoenvironm, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing Coll Life Sci, Beijing, Peoples R China 5.Dali Univ, Inst Eastern Himalaya Biodivers Res, Dali, Peoples R China 6.Queen Mary Univ London, Sch Biol & Chem Sci, London, England 7.Univ Oxford, Dept Archaeol, Palaeogen & Bioarchaeol Res Network, Oxford, England 8.Leibniz Inst Primate Res, German Primate Ctr, Gene Bank Primates & Primate Genet Lab, Gottingen, Germany 9.Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada 10.Gaoligong Mt Natl Nat Reserve, Lushui Management & Conservat Branch, Nujiang, Peoples R China 11.Lushui Forestry & Grassland Council, Nujiang, Peoples R China
推荐引用方式 GB/T 7714	Kuang, Weimin,Hu, Jingyang,Wu, Hong,et al. Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus)[J]. FRONTIERS IN GENETICS,2020,11(无):10.
APA	Kuang, Weimin.,Hu, Jingyang.,Wu, Hong.,Fen, Xiaotian.,Dai, Qingyan.,...&Yu, Li.(2020).Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus).FRONTIERS IN GENETICS,11(无),10.
MLA	Kuang, Weimin,et al."Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus)".FRONTIERS IN GENETICS 11.无(2020):10.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Genetic Diversity, I（1679KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载