Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases

doi:10.3390/cancers14184390

IVPP-IR > 中科院古脊椎所（2000年以后）

	Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases
	Ko, Albert Min-Shan 1; Tu, Hung-Pin 2; Ko, Ying-Chin 3,4
	2022-09-01
发表期刊	CANCERS
卷号	14 期号:18 页码:16
通讯作者	Ko, Ying-Chin(ycko0406@gmail.com)
摘要	Simple Summary Aside from the basic phosphorylation function of alpha-kinase 1 (ALPK1), little is known about its major functions. Researchers have used various forms of biotechnology and human, animal, and cellular models to better understand the relationship of ALPK1 with cancer and cancer-related inflammatory diseases. ALPK1 is involved in the progression of breast, lung, colorectal, oral, and skin cancer as well as lymphoblastic leukemia. ALPK1 has also been implicated in gout, diabetes, and chronic kidney disease, which are thought to be associated with breast, lung, colorectal, urinary tract, pancreatic, and endometrial cancers and lymphoblastic leukemia. ALPK1 upregulates inflammatory cytokines and chemokines during carcinogenesis. The major cytokine involved in carcinogenesis is TNF-alpha, which activates the NF-kappa B pathway, and similar inflammatory responses exist in gout, diabetes, and chronic kidney disease. ALPK1 regulates downstream inflammatory mechanisms that lead to cancer development through certain pathways and plays a key role in cancer initiation and metastasis. Background: Deregulation of conventional protein kinases is associated with the growth and development of cancer cells. Alpha-kinase 1 (ALPK1) belongs to a newly discovered family of serine/threonine protein kinases with no sequence homology to conventional protein kinases, and its function in cancer is poorly understood. Methods: In this systematic review, we searched for and analyzed studies linking ALPK1 to cancer development and progression. Results: Based on the current evidence obtained using human, animal, cellular, and tissue models, ALPK1 is located upstream and triggers cancer cell development and metastasis by regulating the inflammatory response through phosphorylation. Its mRNA and protein levels were found to correlate with advanced tumor size and lymph node metastasis, which occur from the cellular cytoplasm into the nucleus. ALPK1 is also strongly associated with gout, chronic kidney disease, and diabetes, which are considered as inflammatory diseases and associated with cancer. Conclusion: ALPK1 is an oncogene involved in carcinogenesis. Chronic inflammation is the common regulatory mechanism between cancer and these diseases. Future research should focus on identifying inhibitors of serine/threonine and ALPK1 at their phosphorylation sites, which would block various signal transductions and potentially offer kinase-targeted therapeutic agents for patients with cancer and inflammatory diseases.
关键词	ALPK1 chronic kidney disease diabetes gout inflammation oncogene phosphorylation
DOI	10.3390/cancers14184390
关键词[WOS]	CHRONIC KIDNEY-DISEASE ; TYPE-2 DIABETES-MELLITUS ; TUMOR-SUPPRESSOR ; COLORECTAL-CANCER ; GENETIC-VARIANTS ; RISK-FACTORS ; GOUT ; ASSOCIATION ; ALPK1 ; IDENTIFICATION
收录类别	SCI
语种	英语
资助项目	Kaohsiung Medical University Research Foundation[KMU-M111007]
项目资助者	Kaohsiung Medical University Research Foundation
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000858156100001
出版者	MDPI
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/22043
专题	中科院古脊椎所（2000年以后）
通讯作者	Ko, Ying-Chin
作者单位	1.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, CAS, Beijing 100044, Peoples R China 2.Kaohsiung Med Univ, Coll Med, Sch Med, Dept Publ Hlth & Environm Med, Kaohsiung 80756, Taiwan 3.China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 40447, Taiwan 4.Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei 10051, Taiwan
推荐引用方式 GB/T 7714	Ko, Albert Min-Shan,Tu, Hung-Pin,Ko, Ying-Chin. Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases[J]. CANCERS,2022,14(18):16.
APA	Ko, Albert Min-Shan,Tu, Hung-Pin,&Ko, Ying-Chin.(2022).Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases.CANCERS,14(18),16.
MLA	Ko, Albert Min-Shan,et al."Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases".CANCERS 14.18(2022):16.