KMS Institute of Vertebrate Paleontology and Paleoanthropology
| Human genetic history on the Tibetan Plateau in the past 5100 years | |
Wang, Hongru1,17; Yang, Melinda A.1,2; Wangdue, Shargan3; Lu, Hongliang4,5; Chen, Honghai6; Li, Linhui3; Dong, Guanghui7; Tsring, Tinley3; Yuan, Haibing4,5; He, Wei3; Ding, Manyu1,8; Wu, Xiaohong9; Li, Shuai4,5; Tashi, Norbu3; Yang, Tsho3; Yang, Feng4,5; Tong, Yan3; Chen, Zujun3; He, Yuanhong4,5; Cao, Peng1; Dai, Qingyan1; Liu, Feng1; Feng, Xiaotian1; Wang, Tianyi1,8; Yang, Ruowei1; Ping, Wanjing1; Zhang, Zhaoxia1; Gao, Yang10,11; Zhang, Ming6; Wang, Xiaoji11; Zhang, Chao11; Yuan, Kai11; Ko, Albert Min-Shan1; Aldenderfer, Mark12; Gao, Xing1,8 ; Xu, Shuhua10,11,13,14,15; Fu, Qiaomei1,8,16
| |
| 2023-03-17 | |
| 发表期刊 | SCIENCE ADVANCES
 |
| ISSN | 2375-2548 |
| 卷号 | 9期号:11页码:18 |
| 摘要 | Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the present (B.P.) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry across plateau populations, with substantial genetic structure indicating high differentiation before 2500 B.P. Northeastern plateau populations rapidly showed admixture associated with millet farmers by 4700 B.P. in the Gonghe Basin. High genetic similarity on the southern and southwestern plateau showed population expansion along the Yarlung Tsangpo River since 3400 years ago. Central and southeastern plateau populations revealed extensive genetic admixture within the plateau historically, with substantial ancestry related to that found in southern and southwestern plateau populations. Over the past similar to 700 years, substantial gene flow from lowland East Asia further shaped the genetic landscape of present-day plateau populations. The high-altitude adaptive EPAS1 allele was found in plateau populations as early as in a 5100-year-old individual and showed a sharp increase over the past 2800 years. |
| DOI | 10.1126/sciadv.add5582 |
| 关键词[WOS] | PERMANENT HUMAN OCCUPATION ; ANCIENT HUMAN GENOMES ; SKIN PIGMENTATION ; HUMAN SETTLEMENT ; HUMAN-EVOLUTION ; EYE COLOR ; SEQUENCE ; HAIR ; VARIANT ; IDENTIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Chinese Academy of Sciences (CAS) ; National Key R&D Program of China ; National Natural Science Foundation of China[2021YFC1523600] ; Shanghai Qi Zhi Institute[YSBR-019] ; Shanghai Qi Zhi Institute[XDB26000000] ; Tencent Foundation through the XPLORER PRIZE[41925009] ; Tencent Foundation through the XPLORER PRIZE[32030020] ; Howard Hughes Medical Institute ; Key National Social Science Foundation of China ; Basic Science Center Program[55008731] ; Shanghai Municipal Science and Technology Major Project[16ZDA144] ; [32288101] ; [2017SHZDZX01] |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000969832000005 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/22502 |
| 专题 | 中国科学院古脊椎动物与古人类研究所 |
| 通讯作者 | Fu, Qiaomei |
| 作者单位 | 1.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Ctr Excellence Life & Paleoenvironm, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 2.Univ Richmond, Dept Biol, Richmond, VA 23173 USA 3.Tibet Inst Conservat & Res Cultural Rel, Lhasa 850000, Peoples R China 4.Sichuan Univ, Sch Archaeol & Museol, Chengdu 610064, Peoples R China 5.Sichuan Univ, Ctr Archaeol Sci, Chengdu 610064, Peoples R China 6.Northwest Univ, Sch Cultural Heritage, Xian 710069, Peoples R China 7.Lanzhou Univ, Coll Earth & Environm Sci, Key Lab Western Chinas Environm Syst, Minist Educ, Lanzhou 730000, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 9.Peking Univ, Sch Archaeol & Museol, Beijing 100871, Peoples R China 10.Fudan Univ, Ctr Evolutionary Biol, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci,State Key Lab Genet Engn, Shanghai 200438, Peoples R China 11.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Key Lab Computat Biol, Shanghai 200031, Peoples R China 12.Univ Calif Merced, Dept Anthropol & Heritage Studies, Merced, CA 95343 USA 13.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat, Shanghai 200032, Peoples R China 14.Fudan Univ, Human Phenome Inst, Zhangjiang Fudan Int Innovat Ctr, Shanghai 201203, Peoples R China 15.Fudan Univ, Key Lab Contemporary Anthropol, Minist Educ, Shanghai 201203, Peoples R China 16.Shanghai Qi Zhi Inst, Shanghai 200232, Peoples R China 17.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen 518120, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hongru,Yang, Melinda A.,Wangdue, Shargan,et al. Human genetic history on the Tibetan Plateau in the past 5100 years[J]. SCIENCE ADVANCES,2023,9(11):18. |
| APA | Wang, Hongru.,Yang, Melinda A..,Wangdue, Shargan.,Lu, Hongliang.,Chen, Honghai.,...&Fu, Qiaomei.(2023).Human genetic history on the Tibetan Plateau in the past 5100 years.SCIENCE ADVANCES,9(11),18. |
| MLA | Wang, Hongru,et al."Human genetic history on the Tibetan Plateau in the past 5100 years".SCIENCE ADVANCES 9.11(2023):18. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| sciadv.add5582.pdf（1584KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论