How genomic insights into the evolutionary history of clouded leopards inform their conservation

doi:10.1126/sciadv.adh9143

IVPP-IR

	How genomic insights into the evolutionary history of clouded leopards inform their conservation
	Yuan, Jiaqing 1; Wang, Guiqiang 1; Zhao, Le 1,2; Kitchener, Andrew C.3,4; Sun, Ting 1; Chen, Wu 5; Huang, Chen 1; Wang, Chen 5; Xu, Xiao 1; Wang, Jinhong 1; Lu, Huimeng 6; Xu, Lulu 1; Jiangzuo, Qigao 7; Murphy, William J.8; Wu, Dongdong 9; Li, Gang 1,5
	2023-10-06
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	9 期号:40 页码:13
通讯作者	Wu, Dongdong(gli@snnu.edu.cn) ; Li, Gang(wudongdong@mail.kiz.ac.cn)
摘要	Clouded leopards (Neofelis spp.), a morphologically and ecologically distinct lineage of big cats, are severely threatened by habitat loss and fragmentation, targeted hunting, and other human activities. The long-held poor understanding of their genetics and evolution has undermined the effectiveness of conservation actions. Here, we report a comprehensive investigation of the whole genomes, population genetics, and adaptive evolution of Neofelis. Our results indicate the genus Neofelis arose during the Pleistocene, coinciding with glacial-induced climate changes to the distributions of savannas and rainforests, and signatures of natural selection associated with genes functioning in tooth, pigmentation, and tail development, associated with clouded leopards' unique adaptations. Our study highlights high-altitude adaptation as the main factor driving nontaxonomic population differentiation in Neofelis nebulosa. Population declines and inbreeding have led to reduced genetic diversity and the accumulation of deleterious variation that likely affect reproduction of clouded leopards, highlighting the urgent need for effective conservation efforts.
DOI	10.1126/sciadv.adh9143
关键词[WOS]	PHYLOGENETIC ANALYSIS ; NEOFELIS-NEBULOSA ; RAIN-FORESTS ; TOOL ; VISUALIZATION ; ALIGNMENT ; PATTERNS ; PROVIDES ; SYSTEM ; TIGERS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31970391] ; Natural Science Basic Research Program of Shaanxi[2020JM-280] ; Fundamental Research Funds for the Central Universities[GK201902008] ; Fundamental Research Funds for the Central Universities[2020TS054] ; National Science Foundation[DEB-1753760]
项目资助者	National Natural Science Foundation of China ; Natural Science Basic Research Program of Shaanxi ; Fundamental Research Funds for the Central Universities ; National Science Foundation
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001081944500013
出版者	AMER ASSOC ADVANCEMENT SCIENCE
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/22969
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Wu, Dongdong; Li, Gang
作者单位	1.Shaanxi Normal Univ, Coll Life Sci, Xian, Peoples R China 2.Shaanxi Univ Technol, Sch Biosci & Engn, QinLing Bashan Mt Bioresources Comprehens Dev C I, Hanzhong, Peoples R China 3.Natl Museums Scotland, Dept Nat Sci, Chambers St, Edinburgh EH1 1JF, Scotland 4.Univ Edinburgh, Sch Geosci, Drummond St, Edinburgh EH9 3PX, Scotland 5.Guangzhou Wildlife Res Ctr, Guangzhou Zoo, Guangzhou, Peoples R China 6.Northwestern Polytech Univ, Sch Life Sci, Xian, Peoples R China 7.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 8.Texas A&M Univ, Vet Integrat Biosci, College Stn, TX USA 9.Chinese Acad Sci, Kunming Inst Zool, Kunming Nat Hist Museum Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Jiaqing,Wang, Guiqiang,Zhao, Le,et al. How genomic insights into the evolutionary history of clouded leopards inform their conservation[J]. SCIENCE ADVANCES,2023,9(40):13.
APA	Yuan, Jiaqing.,Wang, Guiqiang.,Zhao, Le.,Kitchener, Andrew C..,Sun, Ting.,...&Li, Gang.(2023).How genomic insights into the evolutionary history of clouded leopards inform their conservation.SCIENCE ADVANCES,9(40),13.
MLA	Yuan, Jiaqing,et al."How genomic insights into the evolutionary history of clouded leopards inform their conservation".SCIENCE ADVANCES 9.40(2023):13.