The genome of the black- footed cat: Revealing a rich natural history and urgent conservation priorities for small felids

doi:10.1073/pnas.2310763120

IVPP-IR

	The genome of the black- footed cat: Revealing a rich natural history and urgent conservation priorities for small felids
	Yuan, Jiaqing 1; Kitchener, Andrew C.2,3; Lackey, Laurie Bingaman 4; Sun, Ting 1; Jiangzuo, Qigao 4; Tuohetahong, Yilamujiang 1; Zhao, Le 1,5; Yang, Peng 1; Wang, Guiqiang 1; Huang, Chen 1; Wang, Jinhong 1; Hou, Wenhui 1; Liu, Yang 1; Chen, Wu 6; Mi, Da 7,8; Murphy, William J.9; Li, Gang 1,6
	2024-01-09
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	121 期号:2 页码:11
通讯作者	Yuan, Jiaqing() ; Li, Gang(gli@snnu.edu.cn)
摘要	Habitat degradation and loss of genetic diversity are common threats faced by almost all of today's wild cats. Big cats, such as tigers and lions, are of great concern and have received considerable conservation attention through policies and international actions. However, knowledge of and conservation actions for small wild cats are lagging considerably behind. The black- footed cat, Felis nigripes, one of the smallest felid species, is experiencing increasing threats with a rapid reduction in population size. However, there is a lack of genetic information to assist in developing effective conservation actions. A de novo assembly of a high- quality chromosome- level reference genome of the black- footed cat was made, and comparative genomics and population genomics analyses were carried out. These analyses revealed that the most significant genetic changes in the evolution of the black- footed cat are the rapid evolution of sensory and metabolic- related genes, reflecting genetic adaptations to its characteristic nocturnal hunting and a high metabolic rate. Genomes of the black- footed cat exhibit a high level of inbreeding, especially for signals of recent inbreeding events, which suggest that they may have experienced severe genetic isolation caused by habitat fragmentation. More importantly, inbreeding associated with two deleterious mutated genes may exacerbate the risk of amyloidosis, the dominant disease that causes mortality of about 70% of captive individuals. Our research provides comprehensive documentation of the evolutionary history of the black- footed cat and suggests that there is an urgent need to investigate genomic variations of small felids worldwide to support effective conservation actions.
关键词	black-footed cat introgression conservation inbreeding
DOI	10.1073/pnas.2310763120
关键词[WOS]	HEARING-LOSS ; LIVING CATS ; MUTATION ; AMYLOIDOSIS ; FRAMEWORK ; GENETICS ; IDENTIFICATION ; PLEISTOCENE ; ASSOCIATION ; VARIANTS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31970391] ; Natural Science Basic Research Program of Shaanxi[2020JM-280] ; Fundamental Research Funds forthe Central Universities[GK201902008] ; Guangzhou Collaborative Innovation Center on Science-tech of Ecology and Landscape Program[202206010058] ; NSF[DEB-1753760]
项目资助者	National Natural Science Foundation of China ; Natural Science Basic Research Program of Shaanxi ; Fundamental Research Funds forthe Central Universities ; Guangzhou Collaborative Innovation Center on Science-tech of Ecology and Landscape Program ; NSF
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001167920100003
出版者	NATL ACAD SCIENCES
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/23392
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Yuan, Jiaqing; Li, Gang
作者单位	1.Shaanxi Normal Univ, Coll Life Sci, Xian 710119, Peoples R China 2.Natl Museums Scotland, Dept Nat Sci, Edinburgh EH1 1JF, Scotland 3.Univ Edinburgh, Sch Geosci, Edinburgh EH9 3PX, Scotland 4.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 5.Shaanxi Univ Technol, QinLing Bashan Mt Bioresources Comprehens Dev Coll, Sch Biosci & Engn, Hanzhong 723099, Peoples R China 6.Guangzhou Wildlife Res Ctr, Guangzhou Zoo, Guangzhou 510070, Peoples R China 7.Xian Haorui Genom Technol Co Ltd, Xian 710116, Peoples R China 8.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Xian 710049, Peoples R China 9.Texas A&M Univ, Vet Integrat Biosci, College Stn, TX 77843 USA
推荐引用方式 GB/T 7714	Yuan, Jiaqing,Kitchener, Andrew C.,Lackey, Laurie Bingaman,et al. The genome of the black- footed cat: Revealing a rich natural history and urgent conservation priorities for small felids[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2024,121(2):11.
APA	Yuan, Jiaqing.,Kitchener, Andrew C..,Lackey, Laurie Bingaman.,Sun, Ting.,Jiangzuo, Qigao.,...&Li, Gang.(2024).The genome of the black- footed cat: Revealing a rich natural history and urgent conservation priorities for small felids.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,121(2),11.
MLA	Yuan, Jiaqing,et al."The genome of the black- footed cat: Revealing a rich natural history and urgent conservation priorities for small felids".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121.2(2024):11.