The Born in Guangzhou Cohort Study enables generational genetic discoveries

doi:10.1038/s41586-023-06988-4

IVPP-IR

	The Born in Guangzhou Cohort Study enables generational genetic discoveries
	Huang, Shujia 1; Liu, Siyang 2; Huang, Mingxi 1; He, Jian-Rong 1,3,4; Wang, Chengrui 1; Wang, Tianyi 5,6; Feng, Xiaotian 5,6; Kuang, Yashu 1,3; Lu, Jinhua 1,3; Gu, Yuqin 2; Xia, Xiaoyan 1,7; Lin, Shanshan 1,7; Zhou, Wenhao 8,9; Fu, Qiaomei5,6 ; Xia, Huimin 3,10,11; Qiu, Xiu 1,3,7
	2024-02-15
发表期刊	NATURE
ISSN	0028-0836
卷号	626 期号:7999 页码:565-+
通讯作者	Xia, Huimin(xia.huimin@bigcs.org) ; Qiu, Xiu(xiu.qiu@bigcs.org)
摘要	Genomic research that targets large-scale, prospective birth cohorts constitutes an essential strategy for understanding the influence of genetics and environment on human health(1). Nonetheless, such studies remain scarce, particularly in Asia. Here we present the phase I genome study of the Born in Guangzhou Cohort Study(2) (BIGCS), which encompasses the sequencing and analysis of 4,053 Chinese individuals, primarily composed of trios or mother-infant duos residing in South China. Our analysis reveals novel genetic variants, a high-quality reference panel, and fine-scale local genetic structure within BIGCS. Notably, we identify previously unreported East Asian-specific genetic associations with maternal total bile acid, gestational weight gain and infant cord blood traits. Additionally, we observe prevalent age-specific genetic effects on lipid levels in mothers and infants. In an exploratory intergenerational Mendelian randomization analysis, we estimate the maternal putatively causal and fetal genetic effects of seven adult phenotypes on seven fetal growth-related measurements. These findings illuminate the genetic links between maternal and early-life traits in an East Asian population and lay the groundwork for future research into the intricate interplay of genetics, intrauterine exposures and early-life experiences in shaping long-term health.
DOI	10.1038/s41586-023-06988-4
关键词[WOS]	POPULATION HISTORY ; ADMIXTURE ; BIRTH ; ASIA ; ASSOCIATIONS ; IMPUTATION ; PREGNANCY ; FRAMEWORK ; ANCESTRY ; NORTHERN
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology of the People's Republic of China[2022YFC2702903] ; Ministry of Science and Technology of the People's Republic of China[2022YFC2704601] ; Ministry of Science and Technology of the People's Republic of China[2021ZD0200536] ; National Natural Science Foundation of China[81673181] ; National Natural Science Foundation of China[82173525] ; National Natural Science Foundation of China[31900487] ; National Natural Science Foundation of China[82003471] ; National Natural Science Foundation of China[82273642] ; Guangdong Basic and Applied Basic Research Foundation[2022B1515120080] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515110859] ; Science and Technology Planning Project of Guangdong Province[2019B020227001] ; Science and Technology Planning Project of Guangdong Province[2019B030316014] ; Guangzhou Municipal Science and Technology Bureau[202201020656] ; Guangzhou Municipal Science and Technology Bureau[202102010254] ; Guangzhou Municipal Science and Technology Bureau[202007030002] ; Guangzhou Municipal Health Commission[2023A031001] ; Shenzhen Basic Research Foundation[20220818100717002]
项目资助者	Ministry of Science and Technology of the People's Republic of China ; National Natural Science Foundation of China ; Guangdong Basic and Applied Basic Research Foundation ; Science and Technology Planning Project of Guangdong Province ; Guangzhou Municipal Science and Technology Bureau ; Guangzhou Municipal Health Commission ; Shenzhen Basic Research Foundation
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001163408400005
出版者	NATURE PORTFOLIO
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/23415
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Xia, Huimin; Qiu, Xiu
作者单位	1.Guangzhou Med Univ, Div Birth Cohort Study, Guangzhou Women & Childrens Med Ctr, Guangzhou, Peoples R China 2.Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen Campus, Shenzhen, Peoples R China 3.Prov Clin Res Ctr Child Hlth, Guangzhou, Peoples R China 4.Guangzhou Med Univ, Dept Obstet & Gynecol, Guangzhou Women & Childrens Med Ctr, Guangzhou, Peoples R China 5.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Guangzhou Med Univ, Dept Womens Hlth, Guangzhou Women & Childrens Med Ctr, Prov Key Clin Specialty Woman & Child Hlth, Guangzhou, Peoples R China 8.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Div Neonatol, Guangzhou, Peoples R China 9.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Ctr Newborn Care, Guangzhou, Peoples R China 10.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Prov Key Lab Res Struct Birth Defect Dis, Guangzhou, Peoples R China 11.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Pediat Surg, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Huang, Shujia,Liu, Siyang,Huang, Mingxi,et al. The Born in Guangzhou Cohort Study enables generational genetic discoveries[J]. NATURE,2024,626(7999):565-+.
APA	Huang, Shujia.,Liu, Siyang.,Huang, Mingxi.,He, Jian-Rong.,Wang, Chengrui.,...&Qiu, Xiu.(2024).The Born in Guangzhou Cohort Study enables generational genetic discoveries.NATURE,626(7999),565-+.
MLA	Huang, Shujia,et al."The Born in Guangzhou Cohort Study enables generational genetic discoveries".NATURE 626.7999(2024):565-+.