Empirical correction decomposition method (ECDM): enhancing accuracy of quantitative measurement in spectral CT

doi:10.1088/1361-6560/ad9a4a

IVPP-IR

	Empirical correction decomposition method (ECDM): enhancing accuracy of quantitative measurement in spectral CT
	Wang, Chengmin 1,2; Wang, Zhe 1,3; Li, Mohan 1,3; Liu, Yuedong 1,2; Zhang, Xiaomei 4; Wei, Cunfeng 1,2,3; Wei, Long 1,2,3
	2025-01-05
发表期刊	PHYSICS IN MEDICINE AND BIOLOGY
ISSN	0031-9155
卷号	70 期号:1 页码:16
通讯作者	Wang, Zhe(wangzhe@ihep.ac.cn) ; Wei, Cunfeng(weicf@ihep.ac.cn)
摘要	Objective. Spectral CT and material decomposition methods are crucial for precise material identification and quantitative composition analysis in preclinical research and clinical diagnosis. The empirical material decomposition method is widely used for its straightforward modeling approach, independence from spectral and detector response knowledge, and operational convenience. However, this method has limited decomposition accuracy and its precision depends on the choice of calibration phantoms. Approach. To address these issues, we propose an empirical correction decomposition method (ECDM). The innovation of this method lies in its ability to conveniently estimate and correct empirical decomposition errors using a specially designed calibration phantom. First, the specially designed calibration phantom for ECDM undergoes empirical decomposition initially to establish the relationship between decomposition errors and decomposition values. Then, ECDM estimates and corrects the error of empirical decomposition values. Main results. In the phantom experiments, ECDM improves the decomposition accuracy of empirical methods, effectively reducing the different decomposition errors caused by four different sizes of calibration phantoms from a maximum of 144% to within 25%. In the mouse experiments, ECDM achieves accurate quantification of contrast agents in biological tissues, outperforming the other two methods. The absolute error percentages of ECDM in the decomposition results of the two standard iodine solutions are both less than 5%. Significance. ECDM significantly improves decomposition accuracy and reduces the impact of the size of the empirical calibration phantom. Overall, our method based on spectral CT is very convenient and practical for the quantitative measurement in biomedical applications.
关键词	material decomposition spectral CT quantitative imaging
DOI	10.1088/1361-6560/ad9a4a
关键词[WOS]	IMAGE-RECONSTRUCTION ; ENERGY ; HEMORRHAGE ; ESTIMATOR ; CONTRAST
收录类别	SCI
语种	英语
WOS研究方向	Engineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:001391201200001
出版者	IOP Publishing Ltd
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/24170
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Wang, Zhe; Wei, Cunfeng
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, Beijing Engn Res Ctr Radiog Tech & Equipment, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 100049, Peoples R China 3.Jinan Lab Appl Nucl Sci, Jinan 250131, Peoples R China 4.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China
推荐引用方式 GB/T 7714	Wang, Chengmin,Wang, Zhe,Li, Mohan,et al. Empirical correction decomposition method (ECDM): enhancing accuracy of quantitative measurement in spectral CT[J]. PHYSICS IN MEDICINE AND BIOLOGY,2025,70(1):16.
APA	Wang, Chengmin.,Wang, Zhe.,Li, Mohan.,Liu, Yuedong.,Zhang, Xiaomei.,...&Wei, Long.(2025).Empirical correction decomposition method (ECDM): enhancing accuracy of quantitative measurement in spectral CT.PHYSICS IN MEDICINE AND BIOLOGY,70(1),16.
MLA	Wang, Chengmin,et al."Empirical correction decomposition method (ECDM): enhancing accuracy of quantitative measurement in spectral CT".PHYSICS IN MEDICINE AND BIOLOGY 70.1(2025):16.