KMS Institute of Vertebrate Paleontology and Paleoanthropology
| Impact of intermittent lead exposure on hominid brain evolution | |
| Joannes-Boyau, Renaud1,2,3; de Souza, Janaina Sena4; Arora, Manish5; Austin, Christine5; Westaway, Kira6; Moffat, Ian7,8; Wang, Wei9; Liao, Wei9; Zhang, Yingqi3; Adams, Justin W.2,10,11; Fiorenza, Luca10; Derognat, Flora1; Moncel, Marie-Helene12; Schwartz, Gary T.13; Bailey, Marian1; dos Santos, Filipe F.14,15; Guardia, Gabriela D. A.14; Mercuri, Rafael L. V.14,16; Galante, Pedro A. F.14; Martins, Aline M. A.17,18; Tsu, Blake L.19; Barnes, Christopher A.19; Yates, John18; Petroski, Luiz Pedro20; Sanchez-Sanchez, Sandra M.4; Oviedo, Jose21; Herai, Roberto H.20; Lemos, Bernardo21,22,23; Tonge, Matthew1; Muotri, Alysson R.4,17,24 | |
| 2025-10-15 | |
| 发表期刊 | SCIENCE ADVANCES
 |
| 卷号 | 11期号:42页码:21 |
| 通讯作者 | Joannes-Boyau, Renaud(muotri@ucsd.edu) ; Arora, Manish(manish.arora@mssm.edu) ; Muotri, Alysson R.(renaud.joannes-boyau@scu.edu.au) |
| 摘要 | Gene-environmental interactions shape the evolution of brain architecture and function. Neuro-oncological ventral antigen 1 (NOVA1) is one gene that distinguishes modern humans from extinct hominids. However, the evolutionary pressures that selected the modern NOVA1 allele remain elusive. Here, we show using fossil teeth that several hominids (Australopithecus africanus, Paranthropus robustus, early Homo sp., Gigantopithecus blacki, Pongo sp., Homo neanderthalensis, and Homo sapiens) were consistently exposed to lead over 2 million years, contradicting the idea that lead exposure is solely a modern phenomenon. Moreover, lead exposure on human brain organoids carrying the archaic NOVA1 variant disrupts FOXP2 expression in cortical and thalamic organoids, a gene crucial for the development of human speech and language abilities. Overall, the fossil, cellular, and molecular data support that lead exposure may have contributed to the impact of social and behavioral functioning during evolution, likely affording modern humans a survival advantage. |
| DOI | 10.1126/sciadv.adr1524 |
| 关键词[WOS] | HUMAN TOOTH ENAMEL ; U-SERIES ; GIGANTOPITHECUS-BLACKI ; BONE TURNOVER ; RNA-SEQ ; CHILDREN ; TEETH ; PLEISTOCENE ; EXPRESSION ; PREGNANCY |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | UCSD Archaealization Center ; Neanderthal Brain Foundation ; National Institutes of Health[NIH R01MH100175] ; National Institutes of Health[NIH S10 OD026929] ; California Institute for Regenerative Medicine[DISC4-16377] ; US National Institute of Environmental Health Sciences[R01ES027981] ; Pontificia UniversidadeCatolica do Parana (PUCPR,Curitiba, Brazil) ; Australian Research Council Discovery Grants[DP170101597] ; Australian Research Council Discovery Grants[DP220100195] ; LIEF Grant[LE200100022] ; ARC Discovery Grant[DP230100440] ; ARC Future Fellowship[FT220100184] ; US National Institute of Environmental Health Sciences[P30ES023515] ; US National Institute of Environmental Health Sciences[R01ES026033] ; US National Institute of Environmental Health Sciences[U2CES030859] ; US National Institute of Environmental Health Sciences[U2CES026561] ; US National Institute of Environmental Health Sciences[R35ES030435] ; US National Institute of Environmental Health Sciences[UL1TR004419] ; Monash Interdisciplinary Research Seed Funding Scheme ; National Council for Scientific and Technological Development (CNPq)[311438/2022-9] ; National Council for Scientific and Technological Development (CNPq)[402773/2022-5] ; National Science Foundation (NSF)[BCS 0962564] ; Leakey Foundation ; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior ; Sao Paulo Research Foundation [FAPESP][2023/07144-0] ; Sao Paulo Research Foundation [FAPESP][2020/14158-9] ; Young Scientist Program at Hospital Sirio-Libanes |
| 项目资助者 | UCSD Archaealization Center ; Neanderthal Brain Foundation ; National Institutes of Health ; California Institute for Regenerative Medicine ; US National Institute of Environmental Health Sciences ; Pontificia UniversidadeCatolica do Parana (PUCPR,Curitiba, Brazil) ; Australian Research Council Discovery Grants ; LIEF Grant ; ARC Discovery Grant ; ARC Future Fellowship ; US National Institute of Environmental Health Sciences ; Monash Interdisciplinary Research Seed Funding Scheme ; National Council for Scientific and Technological Development (CNPq) ; National Science Foundation (NSF) ; Leakey Foundation ; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior ; Sao Paulo Research Foundation [FAPESP] ; Young Scientist Program at Hospital Sirio-Libanes |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:001594864900001 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/24888 |
| 专题 | 中国科学院古脊椎动物与古人类研究所 |
| 通讯作者 | Joannes-Boyau, Renaud; Arora, Manish; Muotri, Alysson R. |
| 作者单位 | 1.Southern Cross Univ, Geoarchaeol & Archaeometry Res Grp, Mil Rd, Lismore, NSW 2480, Australia 2.Univ Johannesburg, Palaeo Res Inst, Auckland Pk, ZA-2006 Johannesburg, South Africa 3.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 4.Univ Calif San Diego, Sch Med, Dept Pediat & Cellular & Mol Med, La Jolla, CA 92093 USA 5.Icahn Sch Med Mt Sinai, Dept Environm Med, New York, NY 10029 USA 6.Macquarie Univ, Fac Sci & Engn, Sch Nat Sci, Sydney, NSW 2109, Australia 7.Flinders Univ S Australia, Coll Humanities Arts & Social Sci, Archaeol, Adelaide, SA, Australia 8.Univ Cambridge, McDonald Inst Archaeol Res, Cambridge, England 9.Shandong Univ, Inst Cultural Heritage, Qingdao 266237, Peoples R China 10.Monash Univ, Biomed Discovery Inst, Dept Anat & Dev Biol, Melbourne, Vic 3800, Australia 11.Museums Victoria, Dept Geosci, 11 Nicholson St, Carlton, Vic 3053, Australia 12.Inst Paleontol Humaine, Dept Hommes & Environm, Museum Natl dHistoire Naturelle, CNRS 7194, 1 Rue Rene Panhard, F-75013 Paris, France 13.Arizona State Univ, Inst Human Origins, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA 14.Hosp Sirio Libanes, BR-01308060 Sao Paulo, Brazil 15.Univ Sao Paulo, Dept Bioquim, Inst Quim, Sao Paulo, Brazil 16.Univ Sao Paulo, Interun Bioinformat, Sao Paulo, Brazil 17.UCSD, Sanford Consortium Regenerat Med, ISSCOR Integrated Space Stem Cell Orbital Res, La Jolla, CA 92093 USA 18.Scripps Res Inst, Dept Mol Med, La Jolla, CA 92037 USA 19.NGeneBioAI Inc, 9810 Summers Ridge Rd 100, San Diego, CA 92121 USA 20.Pontific Univ Catol Parana, Sch Med & Life Sci, Grad Program Hlth Sci PUCPR PPGCS, Lab Bioinformat & Neurogenet LaBiN, BR-80215901 Curitiba, Parana, Brazil 21.Univ Arizona, R Ken Coit Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA 22.Harvard TH Chan Sch Publ Hlth, Program Mol & Integrat Physiol Sci, Boston, MA 02115 USA 23.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA 24.Univ Calif San Diego, Kavli Inst Brain & Mind, Ctr Acad Res & Training Anthropogeny CARTA, Archealizat Ctr ArchC, La Jolla, CA 92093 USA |
| 推荐引用方式 GB/T 7714 | Joannes-Boyau, Renaud,de Souza, Janaina Sena,Arora, Manish,et al. Impact of intermittent lead exposure on hominid brain evolution[J]. SCIENCE ADVANCES,2025,11(42):21. |
| APA | Joannes-Boyau, Renaud.,de Souza, Janaina Sena.,Arora, Manish.,Austin, Christine.,Westaway, Kira.,...&Muotri, Alysson R..(2025).Impact of intermittent lead exposure on hominid brain evolution.SCIENCE ADVANCES,11(42),21. |
| MLA | Joannes-Boyau, Renaud,et al."Impact of intermittent lead exposure on hominid brain evolution".SCIENCE ADVANCES 11.42(2025):21. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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