Ancient genomes reveal basal Asian ancestries and dynamic population interactions over time on the southern Tibetan Plateau

doi:10.1016/j.isci.2025.113676

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	Ancient genomes reveal basal Asian ancestries and dynamic population interactions over time on the southern Tibetan Plateau
	Ran, Jingkun 1,2,3; Liu, Yichen 2; Wangdue, Shargan 4; Yang, Xiaoyan 5; Wang, Tianyi 2; Gao, Yu 1; Cao, Peng 2; Tong, Yan 4; Dai, Qingyan 2; Chen, Songtao 6; Shi, Han 2; Liu, Feng 2; Feng, Xiaotian 2; Li, Yazhong 4; Chen, Fahu 1,3,5; Fu, Qiaomei2,3
	2025-11-21
发表期刊	ISCIENCE
卷号	28 期号:11 页码:19
摘要	The southern Tibetan Plateau is a key region for the settlement and flourishing of Tibetan populations, but the long-term population dynamics in this area remain poorly understood. By analyzing 16 newly sequenced genomes from the Mabu Co site (4400 masl), we reconstructed the population history on the southern Tibetan Plateau spanning 4,400-3,500 BP. While the local southern plateau ancestry was maintained over a millennium, genetic diversity within these populations was observed over time. We revealed multiple admixtures, including Basal Asian Xingyi-related ancestry linked to hunter-gatherer populations from southwestern China, and provided the first evidence of this ancestry influencing the ancient southern Tibetan Plateau populations again after 4,000 BP. Moreover, mtDNA and Y haplogroups reveal that individuals exhibit greater maternal genetic diversity alongside restricted paternal lineage conservation. This study provides a higher-resolution population history in the ultra-highlands, contributing to understanding human adaptation to extreme environments.
DOI	10.1016/j.isci.2025.113676
关键词[WOS]	HUMAN OCCUPATION ; GENETIC HISTORY ; DNA ; SETTLEMENT ; CAVE ; ADAPTATION ; ORIGIN
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41925009] ; National Natural Science Foundation of China[41988101] ; Chinese Academy of Science[YSBR-019] ; National Natural Science Foundation of China[41930323] ; Chinese Academy of Sciences[2023000065] ; Second Tibetan Plateau Scientific Expedition and Research Program[2019QZKK060] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2022068]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001604518200001
出版者	CELL PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/25084
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Chen, Fahu; Fu, Qiaomei
作者单位	1.Chinese Acad Sci, Inst Tibetan Plateau Res, State Key Lab Tibetan Plateau Earth Syst Resources, Grp Alpine Paleoecol & Human Adaptat ALPHA, Beijing, Peoples R China 2.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Tibetan Inst Preservat Cultural Rel, Lhasa, Peoples R China 5.Lanzhou Univ, Coll Earth & Environm Sci, Natl Cultural Heritage Adm, Key Sci Res Base Bioarchaeol Cold & Arid Reg,Minis, Lanzhou, Peoples R China 6.Natl Ctr Archaeol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Ran, Jingkun,Liu, Yichen,Wangdue, Shargan,et al. Ancient genomes reveal basal Asian ancestries and dynamic population interactions over time on the southern Tibetan Plateau[J]. ISCIENCE,2025,28(11):19.
APA	Ran, Jingkun.,Liu, Yichen.,Wangdue, Shargan.,Yang, Xiaoyan.,Wang, Tianyi.,...&Fu, Qiaomei.(2025).Ancient genomes reveal basal Asian ancestries and dynamic population interactions over time on the southern Tibetan Plateau.ISCIENCE,28(11),19.
MLA	Ran, Jingkun,et al."Ancient genomes reveal basal Asian ancestries and dynamic population interactions over time on the southern Tibetan Plateau".ISCIENCE 28.11(2025):19.

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