IVPP-IR  > 中科院古脊椎所(2000年以后)
A High-Coverage Genome Sequence from an Archaic Denisovan Individual
Meyer, Matthias1; Kircher, Martin1; Gansauge, Marie-Theres1; Li, Heng2; Racimo, Fernando1; Mallick, Swapan2,3; Schraiber, Joshua G.4; Jay, Flora4; Pruefer, Kay1; de Filippo, Cesare1; Sudmant, Peter H.6; Alkan, Can5,6; Fu, Qiaomei1,7; Do, Ron2; Rohland, Nadin2,3; Tandon, Arti2,3; Siebauer, Michael1; Green, Richard E.8; Bryc, Katarzyna3; Briggs, Adrian W.3; Stenzel, Udo1; Dabney, Jesse1; Shendure, Jay6; Kitzman, Jacob6; Hammer, Michael F.9; Shunkov, Michael V.10; Derevianko, Anatoli P.10; Patterson, Nick2; Andres, Aida M.1; Eichler, Evan E.6,11; Slatkin, Montgomery4; Reich, David2,3; Kelso, Janet1; Paeaebo, Svante1; mmeyer@eva.mpg.de; reich@genetics.med.harvard.edu; paabo@eva.mpg.de
2012-10-12
发表期刊SCIENCE
ISSN0036-8075
卷号338期号:6104页码:222-226
文章类型Article
摘要We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30x) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
关键词Neanderthal Genome Patterns History Hominin Siberia Origin Asia
WOS标题词Science & Technology
URL查看原文
关键词[WOS]NEANDERTHAL GENOME ; PATTERNS ; HISTORY ; HOMININ ; SIBERIA ; ORIGIN ; ASIA
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000309712300037
引用统计
文献类型期刊论文
条目标识符http://119.78.100.205/handle/311034/4247
专题中科院古脊椎所(2000年以后)
通讯作者mmeyer@eva.mpg.de; reich@genetics.med.harvard.edu; paabo@eva.mpg.de
作者单位1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany
2.Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA 02142 USA
3.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
4.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA
5.Bilkent Univ, Dept Comp Engn, TR-06800 Ankara, Turkey
6.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
7.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, CAS MPS Joint Lab Human Evolut, Beijing 100044, Peoples R China
8.Univ Calif Santa Cruz, Jack Baskin Sch Engn, Santa Cruz, CA 95064 USA
9.Univ Arizona, Arizona Res Labs, Div Biotechnol, Tucson, AZ 85721 USA
10.Russian Acad Sci, Siberian Branch, Inst Archaeol & Ethnog, Palaeolith Dept, Novosibirsk 630090, Russia
11.Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA
推荐引用方式
GB/T 7714
Meyer, Matthias,Kircher, Martin,Gansauge, Marie-Theres,et al. A High-Coverage Genome Sequence from an Archaic Denisovan Individual[J]. SCIENCE,2012,338(6104):222-226.
APA Meyer, Matthias.,Kircher, Martin.,Gansauge, Marie-Theres.,Li, Heng.,Racimo, Fernando.,...&paabo@eva.mpg.de.(2012).A High-Coverage Genome Sequence from an Archaic Denisovan Individual.SCIENCE,338(6104),222-226.
MLA Meyer, Matthias,et al."A High-Coverage Genome Sequence from an Archaic Denisovan Individual".SCIENCE 338.6104(2012):222-226.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
High-Coverage Genome(238KB) 开放获取--浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Meyer, Matthias]的文章
[Kircher, Martin]的文章
[Gansauge, Marie-Theres]的文章
百度学术
百度学术中相似的文章
[Meyer, Matthias]的文章
[Kircher, Martin]的文章
[Gansauge, Marie-Theres]的文章
必应学术
必应学术中相似的文章
[Meyer, Matthias]的文章
[Kircher, Martin]的文章
[Gansauge, Marie-Theres]的文章
相关权益政策
中科院和国家自然科学...
收藏/分享
文件名: High-Coverage Genome Sequence from an Archaic Denisovan Individual.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。