KMS Institute of Vertebrate Paleontology and Paleoanthropology
| A High-Coverage Genome Sequence from an Archaic Denisovan Individual | |
| Meyer, Matthias1; Kircher, Martin1; Gansauge, Marie-Theres1; Li, Heng2; Racimo, Fernando1; Mallick, Swapan2,3; Schraiber, Joshua G.4; Jay, Flora4; Pruefer, Kay1; de Filippo, Cesare1; Sudmant, Peter H.6; Alkan, Can5,6; Fu, Qiaomei1,7; Do, Ron2; Rohland, Nadin2,3; Tandon, Arti2,3; Siebauer, Michael1; Green, Richard E.8; Bryc, Katarzyna3; Briggs, Adrian W.3; Stenzel, Udo1; Dabney, Jesse1; Shendure, Jay6; Kitzman, Jacob6; Hammer, Michael F.9; Shunkov, Michael V.10; Derevianko, Anatoli P.10; Patterson, Nick2; Andres, Aida M.1; Eichler, Evan E.6,11; Slatkin, Montgomery4; Reich, David2,3; Kelso, Janet1; Paeaebo, Svante1; mmeyer@eva.mpg.de; reich@genetics.med.harvard.edu; paabo@eva.mpg.de | |
| 2012-10-12 | |
| 发表期刊 | SCIENCE
 |
| ISSN | 0036-8075 |
| 卷号 | 338期号:6104页码:222-226 |
| 文章类型 | Article |
| 摘要 | We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30x) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans. |
| 关键词 | Neanderthal Genome Patterns History Hominin Siberia Origin Asia |
| WOS标题词 | Science & Technology |
| URL | 查看原文 |
| 关键词[WOS] | NEANDERTHAL GENOME ; PATTERNS ; HISTORY ; HOMININ ; SIBERIA ; ORIGIN ; ASIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000309712300037 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/4247 |
| 专题 | 中科院古脊椎所（2000年以后） |
| 通讯作者 | mmeyer@eva.mpg.de; reich@genetics.med.harvard.edu; paabo@eva.mpg.de |
| 作者单位 | 1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 2.Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA 02142 USA 3.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 4.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 5.Bilkent Univ, Dept Comp Engn, TR-06800 Ankara, Turkey 6.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA 7.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, CAS MPS Joint Lab Human Evolut, Beijing 100044, Peoples R China 8.Univ Calif Santa Cruz, Jack Baskin Sch Engn, Santa Cruz, CA 95064 USA 9.Univ Arizona, Arizona Res Labs, Div Biotechnol, Tucson, AZ 85721 USA 10.Russian Acad Sci, Siberian Branch, Inst Archaeol & Ethnog, Palaeolith Dept, Novosibirsk 630090, Russia 11.Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA |
| 推荐引用方式 GB/T 7714 | Meyer, Matthias,Kircher, Martin,Gansauge, Marie-Theres,et al. A High-Coverage Genome Sequence from an Archaic Denisovan Individual[J]. SCIENCE,2012,338(6104):222-226. |
| APA | Meyer, Matthias.,Kircher, Martin.,Gansauge, Marie-Theres.,Li, Heng.,Racimo, Fernando.,...&paabo@eva.mpg.de.(2012).A High-Coverage Genome Sequence from an Archaic Denisovan Individual.SCIENCE,338(6104),222-226. |
| MLA | Meyer, Matthias,et al."A High-Coverage Genome Sequence from an Archaic Denisovan Individual".SCIENCE 338.6104(2012):222-226. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| High-Coverage Genome（238KB） | 开放获取 | -- | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论