KMS Institute of Vertebrate Paleontology and Paleoanthropology
| Dynamics of morphological changes for mitochondrial fission and fusion | |
Wang ShiQi1,2,4 ; Fu ChangLiang1,2; Zhang Yan1,2; Chen Quan3; Long Mian1,2; mlong@imech.ac.cn
| |
| 2010-04-01 | |
| 发表期刊 | SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
 |
| ISSN | 1674-7348 |
| 卷号 | 53期号:4页码:680-689 |
| 文章类型 | Article |
| 摘要 | Mitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, which depended on the time-dependent distribution of the mitochondrial volume and the fission and fusion rates. Parametric analysis was done for two typical volume distributions. One was Gamma distribution and the other was Gaussian distribution, derived from the measurements of volume distribution for individual mitochondria in a living cell and purified mitochondria in vitro. The predictions indicated that the survival probability strongly depended on morphological changes of individual mitochondria and was inversely correlated to the fission and fusion rates. This work provided a new insight into quantifying the mitochondrial dynamics via monitoring the evolution of the mitochondrial volume. |
| 关键词 | Mitochondria Morphology Fission Fusion Dynamics Modeling |
| WOS标题词 | Science & Technology ; Physical Sciences |
| URL | 查看原文 |
| 关键词[WOS] | LIVING CELLS ; RETICULUM ; TRANSPORT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Physics |
| WOS类目 | Physics, Multidisciplinary |
| WOS记录号 | WOS:000276776100012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/4585 |
| 专题 | 中科院古脊椎所（2000年以后） 古哺乳动物研究室 |
| 通讯作者 | mlong@imech.ac.cn |
| 作者单位 | 1.Natl Micrograv Lab, Key Lab Micrograv, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang ShiQi,Fu ChangLiang,Zhang Yan,et al. Dynamics of morphological changes for mitochondrial fission and fusion[J]. SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY,2010,53(4):680-689. |
| APA | Wang ShiQi,Fu ChangLiang,Zhang Yan,Chen Quan,Long Mian,&mlong@imech.ac.cn.(2010).Dynamics of morphological changes for mitochondrial fission and fusion.SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY,53(4),680-689. |
| MLA | Wang ShiQi,et al."Dynamics of morphological changes for mitochondrial fission and fusion".SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY 53.4(2010):680-689. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Dynamics of morpholo（865KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论