| The complete genome sequence of a Neanderthal from the Altai Mountains | |
| Pruefer, Kay1; Racimo, Fernando2; Patterson, Nick3; Jay, Flora2; Sankararaman, Sriram3,4; Sawyer, Susanna1; Heinze, Anja1; Renaud, Gabriel1; Sudmant, Peter H.5; de Filippo, Cesare1; Li, Heng3; Mallick, Swapan3,4,7,8; Dannemann, Michael1; Fu, Qiaomei1,6; Kircher, Martin1,5; Kuhlwilm, Martin1; Lachmann, Michael1; Meyer, Matthias1; Ongyerth, Matthias1; Siebauer, Michael1; Theunert, Christoph1; Tandon, Arti3,4; Moorjani, Priya4; Pickrell, Joseph4; Mullikin, James C.; Vohr, Samuel H.9; Green, Richard E.9; Hellmann, Ines10; Johnson, Philip L. F.11; Blanche, Helene12; Cann, Howard12; Kitzman, Jacob O.5; Shendure, Jay5; Eichler, Evan E.5,13; Lein, Ed S.14; Bakken, Trygve E.14; Golovanova, Liubov V.15; Doronichev, Vladimir B.15; Shunkov, Michael V.16; Derevianko, Anatoli P.16; Viola, Bence17; Slatkin, Montgomery2; Reich, David3,4,18; Kelso, Janet1; Paeaebo, Svante1; Slatkin, M (reprint author), Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA. | |
| 2014-01-02 | |
| 发表期刊 | NATURE
 |
| ISSN | 0028-0836 |
| 卷号 | 505期号:7481页码:43-+ |
| 文章类型 | Article |
| 摘要 | We present a high-quality genome sequence of a Neanderthal woman from Siberia. We show that her parents were related at the level of half-siblings and that mating among close relatives was common among her recent ancestors. We also sequenced the genome of a Neanderthal from the Caucasus to low coverage. An analysis of the relationships and population history of available archaic genomes and 25 present-day human genomes shows that several gene flow events occurred among Neanderthals, Denisovans and early modern humans, possibly including gene flow into Denisovans from an unknown archaic group. Thus, interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene. In addition, the high-quality Neanderthal genome allows us to establish a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans. |
| WOS标题词 | Science & Technology |
| 关键词[WOS] | ANCIENT DNA ; POPULATION HISTORY ; MEZMAISKAYA CAVE ; HUMAN-EVOLUTION ; GREAT APE ; ADMIXTURE ; ANCESTRY ; HOMININ ; SIBERIA ; ASIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | NSF [1032255]; NIH [GM100233, HG002385, R01-GM40282]; National Genome Research Institute (NHGRI) [HG006283]; Harvard University Science of the Human Past Program; HHMI International Student Fellowship; Paul G. Allen Family Foundation; Presidential Innovation Fund of the Max Planck Society |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000329163300020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/5190 |
| 专题 | 古人类及旧石器研究室 |
| 通讯作者 | Slatkin, M (reprint author), Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA. |
| 作者单位 | 1.Max Planck Inst Evolutionare Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 2.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 3.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA 4.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 5.Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA 6.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 7.NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA 8.NHGRI, NIH Intramural Sequencing Ctr, NIH, Bethesda, MD 20892 USA 9.Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA 10.Max F Perutz Labs, Math & Biosci Grp, Campus Vienna Bioctr 5, A-1030 Vienna, Austria 11.Emory Univ, Dept Biol, Atlanta, GA 30322 USA 12.Ctr Etud Polymorphisme Humain, Fdn Jean Dausset, F-75010 Paris, France 13.Howard Hughes Med Inst, Seattle, WA 98195 USA 14.Allen Inst Brain Sci, Seattle, WA 98103 USA 15.ANO Lab Prehist 14 Linia 3 11, St Petersburg 199034, Russia 16.Russian Acad Sci, Inst Archaeol & Ethnog, Palaeolith Dept, Siberian Branch, Novosibirsk 630090, Russia 17.Max Planck Inst Evolutionare Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany 18.Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Pruefer, Kay,Racimo, Fernando,Patterson, Nick,et al. The complete genome sequence of a Neanderthal from the Altai Mountains[J]. NATURE,2014,505(7481):43-+. |
| APA | Pruefer, Kay.,Racimo, Fernando.,Patterson, Nick.,Jay, Flora.,Sankararaman, Sriram.,...&Slatkin, M .(2014).The complete genome sequence of a Neanderthal from the Altai Mountains.NATURE,505(7481),43-+. |
| MLA | Pruefer, Kay,et al."The complete genome sequence of a Neanderthal from the Altai Mountains".NATURE 505.7481(2014):43-+. |
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| nature12886.pdf（2042KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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