KMS Institute of Vertebrate Paleontology and Paleoanthropology
| Molecular development of fibular reduction in birds and its evolution from dinosaurs | |
| Francisco Botelho, Joao1; Smith-Paredes, Daniel1; Soto-Acuna, Sergio1,2; O'Connor, Jingmai3; Palma, Veronica4; Vargas, Alexander O.1 | |
| 2016-03-01 | |
| 发表期刊 | EVOLUTION
 |
| 卷号 | 70期号:3页码:543-554 |
| 文章类型 | Article |
| 摘要 | Birds have a distally reduced, splinter-like fibula that is shorter than the tibia. In embryonic development, both skeletal elements start out with similar lengths. We examined molecular markers of cartilage differentiation in chicken embryos. We found that the distal end of the fibula expresses Indian hedgehog (IHH), undergoing terminal cartilage differentiation, and almost no Parathyroid-related protein (PTHrP), which is required to develop a proliferative growth plate (epiphysis). Reduction of the distal fibula may be influenced earlier by its close contact with the nearby fibulare, which strongly expresses PTHrP. The epiphysis-like fibulare however then separates from the fibula, which fails to maintain a distal growth plate, and fibular reduction ensues. Experimental downregulation of IHH signaling at a postmorphogenetic stage led to a tibia and fibula of equal length: The fibula is longer than in controls and fused to the fibulare, whereas the tibia is shorter and bent. We propose that the presence of a distal fibular epiphysis may constrain greater growth in the tibia. Accordingly, many Mesozoic birds show a fibula that has lost its distal epiphysis, but remains almost as long as the tibia, suggesting that loss of the fibulare preceded and allowed subsequent evolution of great fibulo-tibial disparity. |
| 关键词 | Bird-dinosaur Transition Fibula Ihh Mesozoic Birds Pthrp Zeugopod |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1111/evo.12882 |
| 关键词[WOS] | HORMONE-RELATED-PROTEIN ; INDIAN HEDGEHOG CONTROL ; REGULATED BONE-GROWTH ; SKELETON FORMATION ; ENDOCHONDRAL BONE ; CARTILAGE DIFFERENTIATION ; ALLIGATOR-MISSISSIPPIENSIS ; SAPEORNIS-CHAOYANGENSIS ; TETRAPOD LIMB ; BASAL BIRD |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | FONDECYT, Government of Chile(1150906) |
| WOS研究方向 | Environmental Sciences & Ecology ; Evolutionary Biology ; Genetics & Heredity |
| WOS类目 | Ecology ; Evolutionary Biology ; Genetics & Heredity |
| WOS记录号 | WOS:000372464600003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/7050 |
| 专题 | 中科院古脊椎所（2000年以后） |
| 作者单位 | 1.Univ Chile, Fac Ciencias, Dept Biol, Lab Ontogenia & Filogenia, Santiago, Chile 2.Museo Nacl Hist Nat, Area Paleontol, Santiago, Chile 3.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing, Peoples R China 4.Univ Chile, Fac Ciencias, Dept Biol, FONDAP Ctr Genom Regulat, Santiago, Chile |
| 推荐引用方式 GB/T 7714 | Francisco Botelho, Joao,Smith-Paredes, Daniel,Soto-Acuna, Sergio,et al. Molecular development of fibular reduction in birds and its evolution from dinosaurs[J]. EVOLUTION,2016,70(3):543-554. |
| APA | Francisco Botelho, Joao,Smith-Paredes, Daniel,Soto-Acuna, Sergio,O'Connor, Jingmai,Palma, Veronica,&Vargas, Alexander O..(2016).Molecular development of fibular reduction in birds and its evolution from dinosaurs.EVOLUTION,70(3),543-554. |
| MLA | Francisco Botelho, Joao,et al."Molecular development of fibular reduction in birds and its evolution from dinosaurs".EVOLUTION 70.3(2016):543-554. |
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| Molecular developmen（1136KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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