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Molecular development of fibular reduction in birds and its evolution from dinosaurs
Francisco Botelho, Joao1; Smith-Paredes, Daniel1; Soto-Acuna, Sergio1,2; O'Connor, Jingmai3; Palma, Veronica4; Vargas, Alexander O.1
2016-03-01
发表期刊EVOLUTION
卷号70期号:3页码:543-554
文章类型Article
摘要Birds have a distally reduced, splinter-like fibula that is shorter than the tibia. In embryonic development, both skeletal elements start out with similar lengths. We examined molecular markers of cartilage differentiation in chicken embryos. We found that the distal end of the fibula expresses Indian hedgehog (IHH), undergoing terminal cartilage differentiation, and almost no Parathyroid-related protein (PTHrP), which is required to develop a proliferative growth plate (epiphysis). Reduction of the distal fibula may be influenced earlier by its close contact with the nearby fibulare, which strongly expresses PTHrP. The epiphysis-like fibulare however then separates from the fibula, which fails to maintain a distal growth plate, and fibular reduction ensues. Experimental downregulation of IHH signaling at a postmorphogenetic stage led to a tibia and fibula of equal length: The fibula is longer than in controls and fused to the fibulare, whereas the tibia is shorter and bent. We propose that the presence of a distal fibular epiphysis may constrain greater growth in the tibia. Accordingly, many Mesozoic birds show a fibula that has lost its distal epiphysis, but remains almost as long as the tibia, suggesting that loss of the fibulare preceded and allowed subsequent evolution of great fibulo-tibial disparity.
关键词Bird-dinosaur Transition Fibula Ihh Mesozoic Birds Pthrp Zeugopod
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1111/evo.12882
关键词[WOS]HORMONE-RELATED-PROTEIN ; INDIAN HEDGEHOG CONTROL ; REGULATED BONE-GROWTH ; SKELETON FORMATION ; ENDOCHONDRAL BONE ; CARTILAGE DIFFERENTIATION ; ALLIGATOR-MISSISSIPPIENSIS ; SAPEORNIS-CHAOYANGENSIS ; TETRAPOD LIMB ; BASAL BIRD
收录类别SCI
语种英语
项目资助者FONDECYT, Government of Chile(1150906)
WOS研究方向Environmental Sciences & Ecology ; Evolutionary Biology ; Genetics & Heredity
WOS类目Ecology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号WOS:000372464600003
引用统计
文献类型期刊论文
条目标识符http://119.78.100.205/handle/311034/7050
专题中科院古脊椎所(2000年以后)
作者单位1.Univ Chile, Fac Ciencias, Dept Biol, Lab Ontogenia & Filogenia, Santiago, Chile
2.Museo Nacl Hist Nat, Area Paleontol, Santiago, Chile
3.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing, Peoples R China
4.Univ Chile, Fac Ciencias, Dept Biol, FONDAP Ctr Genom Regulat, Santiago, Chile
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GB/T 7714
Francisco Botelho, Joao,Smith-Paredes, Daniel,Soto-Acuna, Sergio,et al. Molecular development of fibular reduction in birds and its evolution from dinosaurs[J]. EVOLUTION,2016,70(3):543-554.
APA Francisco Botelho, Joao,Smith-Paredes, Daniel,Soto-Acuna, Sergio,O'Connor, Jingmai,Palma, Veronica,&Vargas, Alexander O..(2016).Molecular development of fibular reduction in birds and its evolution from dinosaurs.EVOLUTION,70(3),543-554.
MLA Francisco Botelho, Joao,et al."Molecular development of fibular reduction in birds and its evolution from dinosaurs".EVOLUTION 70.3(2016):543-554.
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文件名: Molecular development of fibular reduction in birds and its evolution from dinosaurs - Botelho - 2016 - Evolution - Wiley Online Library.pdf
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