KMS Institute of Vertebrate Paleontology and Paleoanthropology
| A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years | |
| Moorjani, Priya1,2; Sankararaman, Sriram3,4,5; Fu, Qiaomei3,6; Przeworski, Molly1,7; Patterson, Nick2; Reich, David2,3,8 | |
| 2016-05-17 | |
| 发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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| 卷号 | 113期号:20页码:5652-5657 |
| 文章类型 | Article |
| 摘要 | The study of human evolution has been revolutionized by inferences from ancient DNA analyses. Key to these studies is the reliable estimation of the age of ancient specimens. High-resolution age estimates can often be obtained using radiocarbon dating, and, while precise and powerful, this method has some biases, making it of interest to directly use genetic data to infer a date for samples that have been sequenced. Here, we report a genetic method that uses the recombination clock. The idea is that an ancient genome has evolved less than the genomes of present-day individuals and thus has experienced fewer recombination events since the common ancestor. To implement this idea, we take advantage of the insight that all non-Africans have a common heritage of Neanderthal gene flow into their ancestors. Thus, we can estimate the date since Neanderthal admixture for present-day and ancient samples simultaneously and use the difference as a direct estimate of the ancient specimen's age. We apply our method to date five Upper Paleolithic Eurasian genomes with radiocarbon dates between 12,000 and 45,000 y ago and show an excellent correlation of the genetic and C-14 dates. By considering the slope of the correlation between the genetic dates, which are in units of generations, and the C-14 dates, which are in units of years, we infer that the mean generation interval in humans over this period has been 26-30 y. Extensions of this methodology that use older shared events may be applicable for dating beyond the radiocarbon frontier. |
| 关键词 | Molecular Clock Generation Interval Ancient Dna Branch Shortening |
| WOS标题词 | Science & Technology |
| DOI | 10.1073/pnas.1514696113 |
| 关键词[WOS] | NEANDERTHAL ANCESTRY ; HUMAN-POPULATIONS ; RECOMBINATION ; ADMIXTURE ; SEQUENCE ; LANDSCAPE ; LINEAGES ; HOTSPOTS ; HISTORY ; MAP |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | National Institutes of Health (NIH) under Ruth L. Kirschstein National Research Service Award(F32 GM115006-01) ; NIH(5K99GM111744-02 ; National Natural Science Foundation of China(L1524016) ; Chinese Academy of Sciences Discipline Development Strategy Project(2015-DX-C-03) ; US National Institutes of Health(R01 GM83098 ; US National Science Foundation HOMINID Grant(BCS-1032255) ; 4R00GM111744-03) ; GM100233) |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000375977600052 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/7086 |
| 专题 | 中科院古脊椎所（2000年以后） |
| 作者单位 | 1.Columbia Univ, Dept Biol Sci, New York, NY 10027 USA 2.Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA 3.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 4.Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90095 USA 5.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA 6.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 7.Columbia Univ, Dept Syst Biol, New York, NY 10027 USA 8.Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Moorjani, Priya,Sankararaman, Sriram,Fu, Qiaomei,et al. A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(20):5652-5657. |
| APA | Moorjani, Priya,Sankararaman, Sriram,Fu, Qiaomei,Przeworski, Molly,Patterson, Nick,&Reich, David.(2016).A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(20),5652-5657. |
| MLA | Moorjani, Priya,et al."A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.20(2016):5652-5657. |
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