KMS Institute of Vertebrate Paleontology and Paleoanthropology
| Ancient gene flow from early modern humans into Eastern Neanderthals | |
| Kuhlwilm, Martin1; Gronau, Ilan2; Hubisz, Melissa J.3; de Filippo, Cesare1; Prado-Martinez, Javier4; Kircher, Martin1,5; Fu, Qiaomei1,6,7; Burbano, Hernan A.1,8; Lalueza-Fox, Carles4; de la Rasilla, Marco9; Rosas, Antonio10; Rudan, Pavao11; Brajkovic, Dejana12; Kucan, Zeljko11; Gusic, Ivan11; Marques-Bonet, Tomas4,13,14; Andres, Aida M.1; Viola, Bence15,16; Paeaebo, Svante1; Meyer, Matthias1; Siepel, Adam3,17; Castellano, Sergi1 | |
| 2016-02-25 | |
| 发表期刊 | NATURE
 |
| 卷号 | 530期号:7591页码:429-+ |
| 文章类型 | Article |
| 摘要 | It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a population that diverged early from other modern humans in Africa contributed genetically to the ancestors of Neanderthals from the Altai Mountains roughly 100,000 years ago. By contrast, we do not detect such a genetic contribution in the Denisovan or the two European Neanderthals. We conclude that in addition to later interbreeding events, the ancestors of Neanderthals from the Altai Mountains and early modern humans met and interbred, possibly in the Near East, many thousands of years earlier than previously thought. |
| WOS标题词 | Science & Technology |
| DOI | 10.1038/nature16544 |
| 关键词[WOS] | GENOME SEQUENCE ; TRANSCRIPTION FACTOR ; HUMAN-POPULATIONS ; DNA ; SELECTION ; SOUTHERN ; HISTORY ; INFERENCE ; ANCESTRY ; PATTERNS |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | National Science Foundation(DGE-1144153) ; Special Foundation of the President of the Chinese Academy of Sciences ; ICREA ; EMBO YIP ; Fundacio Barcelona Zoo ; Max Planck Society ; Krekeler Foundation ; MINECO(BFU2014-55090-P FEDER ; US National Institutes of Health(GM102192 ; BFU2015-7116-ERC ; U01 MH106874) ; BFU2015-6215-ERC ; BFU2012-34157 FEDER) |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000370690800025 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/7135 |
| 专题 | 中科院古脊椎所（2000年以后） |
| 作者单位 | 1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 2.Herzliya Interdisciplinary Ctr IDC, Efi Arazi Sch Comp Sci, IL-46150 Herzliyya, Israel 3.Cornell Univ, Dept Biol Stat & Computat Biol, Ithaca, NY 14850 USA 4.Inst Evolutionary Biol UPF CSIC, Barcelona 08003, Spain 5.Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA 6.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 7.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins Chinese, IVPP, Beijing 100044, Peoples R China 8.Max Planck Inst Dev Biol, Dept Mol Biol, D-72076 Tubingen, Germany 9.Univ Oviedo, Dept Hist, Area Prehist, Oviedo 33011, Spain 10.CSIC, Museo Nacl Ciencias Nat, Dept Paleobiol, Plaza Murillo 2, E-28006 Madrid, Spain 11.Croatian Acad Sci & Arts, Anthropol Ctr, Zagreb 10000, Croatia 12.Croatian Acad Sci & Arts, Inst Quaternary Paleontol & Geol, Zagreb 10000, Croatia 13.Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain 14.Ctr Nacl Anal Genom CRG CNAG, Barcelona 08028, Spain 15.Univ Toronto, Dept Anthropol, Toronto, ON M5S 2S2, Canada 16.Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany 17.Cold Spring Harbor Lab, Simons Ctr Quantitat Biol, Cold Spring Harbor, NY 11724 USA |
| 推荐引用方式 GB/T 7714 | Kuhlwilm, Martin,Gronau, Ilan,Hubisz, Melissa J.,et al. Ancient gene flow from early modern humans into Eastern Neanderthals[J]. NATURE,2016,530(7591):429-+. |
| APA | Kuhlwilm, Martin.,Gronau, Ilan.,Hubisz, Melissa J..,de Filippo, Cesare.,Prado-Martinez, Javier.,...&Castellano, Sergi.(2016).Ancient gene flow from early modern humans into Eastern Neanderthals.NATURE,530(7591),429-+. |
| MLA | Kuhlwilm, Martin,et al."Ancient gene flow from early modern humans into Eastern Neanderthals".NATURE 530.7591(2016):429-+. |
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| out (8).pdf（2353KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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