KMS Institute of Vertebrate Paleontology and Paleoanthropology
| Ancient human genomes suggest three ancestral populations for present-day Europeans | |
| Lazaridis, Iosif1,2; Patterson, Nick2; Mittnik, Alissa3; Renaud, Gabriel4; Mallick, Swapan1,2; Kirsanow, Karola5; Sudmant, Peter H.6; Schraiber, Joshua G.6,7; Castellano, Sergi4; Lipson, Mark8,9; Berger, Bonnie2,8,9; Economou, Christos10; Bollongino, Ruth5; Fu, Qiaomei1,4,11; Bos, Kirsten I.3; Nordenfelt, Susanne1,2; Li, Heng1,2; de Filippo, Cesare4; Pruefer, Kay4; Sawyer, Susanna4; Posth, Cosimo3; Haak, Wolfgang12; Hallgren, Fredrik13; Fornander, Elin13; Rohland, Nadin1,2; Delsate, Dominique14,15; Francken, Michael16; Guinet, Jean-Michel14; Wahl, Joachim17; Ayodo, George18; Babiker, Hamza A.19,20,21,22; Bailliet, Graciela23,24; Balanovska, Elena25; Balanovsky, Oleg25,26; Barrantes, Ramiro27; Bedoya, Gabriel28; Ben-Ami, Haim29; Bene, Judit30,31; Berrada, Fouad32; Bravi, Claudio M.23,24; Brisighelli, Francesca33; Busby, George B. J.34,35; Cali, Francesco36; Churnosov, Mikhail37; Cole, David E. C.38; Corach, Daniel39; Damba, Larissa40; van Driem, George41; Dryomov, Stanislav42; Dugoujon, Jean-Michel43; Fedorova, Sardana A.44,45; Romero, Irene Gallego46; Gubina, Marina40; Hammer, Michael47; Henn, Brenna M.48; Hervig, Tor49; Hodoglugil, Ugur50; Jha, Aashish R.46; Karachanak-Yankova, Sena51; Khusainova, Rita52,53; Khusnutdinova, Elza52,53; Kittles, Rick54; Kivisild, Toomas55; Klitz, William7; Kucinskas, Vaidutis56; Kushniarevich, Alena57; Laredj, Leila58; Litvinov, Sergey52,53,57; Loukidis, Theologos59; Mahley, Robert W.60; Melegh, Bela30,31; Metspalu, Ene61; Molina, Julio62; Mountain, Joanna63; Nakkalajarvi, Klemetti64; Nesheva, Desislava51; Nyambo, Thomas65; Osipova, Ludmila40; Parik, Jueri61; Platonov, Fedor66; Posukh, Olga40; Romano, Valentino67; Rothhammer, Francisco68,69,70; Rudan, Igor71; Ruizbakiev, Ruslan72; Sahakyan, Hovhannes57,73; Sajantila, Antti74,75; Salas, Antonio76,77; Starikovskaya, Elena B.42; Tarekegn, Ayele78; Toncheva, Draga51; Turdikulova, Shahlo79; Uktveryte, Ingrida56; Utevska, Olga80; Vasquez, Rene81,82; Villena, Mercedes81,82; Voevoda, Mikhail40,83,84; Winkler, Cheryl A.85; Yepiskoposyan, Levon73; Zalloua, Pierre86,87; Zemunik, Tatijana88; Cooper, Alan12; Capelli, Cristian34; Thomas, Mark G.59; Ruiz-Linares, Andres59; Tishkoff, Sarah A.89; Singh, Lalji90; Thangaraj, Kumarasamy90; Villems, Richard57,61,91; Comas, David92; Sukernik, Rem42; Metspalu, Mait57; Meyer, Matthias4; Eichler, Evan E.6,93; Burger, Joachim5; Slatkin, Montgomery7; Paeaebo, Svante4; Kelso, Janet4; Reich, David1,2,94; Krause, Johannes3,95,96 | |
| 2014-09-18 | |
| 发表期刊 | NATURE
 |
| 卷号 | 513期号:7518页码:409-+ |
| 文章类型 | Article |
| 摘要 | We sequenced the genomes of a similar to 7,000-year-old farmer from Germany and eight similar to 8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes(1-4) with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians(3), who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had similar to 44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages. |
| WOS标题词 | Science & Technology |
| 关键词[WOS] | DNA-SEQUENCING DATA ; GENETIC DIVERSITY ; HUNTER-GATHERERS ; WIDE ASSOCIATION ; HISTORY ; ADMIXTURE ; NEANDERTHAL ; FARMERS ; AFRICA ; CAVE |
| 收录类别 | SCI ; AHCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000341814900058 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/7347 |
| 专题 | 中科院古脊椎所（2000年以后） |
| 作者单位 | 1.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 2.Broad Inst Harvard & MIT, Cambridge, MA 02142 USA 3.Univ Tubingen, Inst Archaeol Sci, D-72074 Tubingen, Germany 4.Max Planck Inst Evolutionare Anthropol, D-04103 Leipzig, Germany 5.Johannes Gutenberg Univ Mainz, Inst Anthropol, D-55128 Mainz, Germany 6.Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA 7.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 8.MIT, Dept Math & Comp Sci, Cambridge, MA 02139 USA 9.MIT, Artificial Intelligence Lab, Cambridge, MA 02139 USA 10.Stockholm Univ, Archaeol Res Lab, S-11418 Stockholm, Sweden 11.Chinese Acad Sci, IVPP, Key Lab Vertebrate Evolut & Human Origins, Beijing 100049, Peoples R China 12.Univ Adelaide, Sch Earth & Environm Sci, Australian Ctr Ancient DNA & Environm Inst, Adelaide, SA 5005, Australia 13.Cultural Heritage Fdn, S-72212 Vasteras, Sweden 14.Natl Museum Nat Hist, L-2160 Luxembourg, Luxembourg 15.Natl Museum Nat Hist, Natl Ctr Archaeol Res, L-2160 Luxembourg, Luxembourg 16.Univ Tubingen, Senckenberg Ctr Human Evolut & Paleoenvironm, Dept Paleoanthropol, D-72070 Tubingen, Germany 17.State Off Cultural Heritage Management Baden Wurt, D-78467 Constance, Germany 18.Ctr Global Hlth & Child Dev, Kisumu 40100, Kenya 19.Univ Edinburgh, Sch Biol Sci, Inst Evolut Res, Edinburgh EH9 3JT, Midlothian, Scotland 20.Univ Edinburgh, Sch Biol Sci, Inst Immunol Res, Edinburgh EH9 3JT, Midlothian, Scotland 21.Univ Edinburgh, Sch Biol Sci, Inst Infect Res, Edinburgh EH9 3JT, Midlothian, Scotland 22.Sultan Qaboos Univ, Fac Med, Dept Biochem, Muscat 123, Oman 23.Consejo Nacl Invest Cient & Tecn, CCT, Inst Multidisciplinario Biol Celular IMBICE, Lab Genet Mol Poblac, La Plata, Buenos Aires, Argentina 24.CICPBA, La Plata, Buenos Aires, Argentina 25.Russian Acad Med Sci, Med Genet Res Ctr, Moscow 115478, Russia 26.NI Vavilov Gen Genet Res Inst, Moscow 119991, Russia 27.Univ Costa Rica, Escuela Biol, San Jose 2060, Costa Rica 28.Univ Antioquia, Res Grp GENMOL, Inst Biol, Medellin, Colombia 29.Rambam Hlth Care Campus, IL-31096 Haifa, Israel 30.Univ Pecs, Dept Med Genet, H-7624 Pecs, Hungary 31.Univ Pecs, Szentagothai Res Ctr, H-7624 Pecs, Hungary 32.Al Akhawayn Univ Ifrane AUI, Sch Sci & Engn, Ifrane 53000, Morocco 33.Univ Cattolica Sacro Cuore, Inst Legal Med, Forens Genet Lab, I-00168 Rome, Italy 34.Univ Oxford, Dept Zool, Oxford OX1 3PS, England 35.Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England 36.IRCCS Assoc Oasi Maria SS, Genet Mol Lab, I-94018 Troina, Italy 37.Belgorod State Univ, Belgorod 308015, Russia 38.Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1L5, Canada 39.Univ Buenos Aires, Sch Pharm & Biochem, Serv Huellas Digitales Genet, RA-1113 Caba, Argentina 40.Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia 41.Univ Bern, Inst Linguist, CH-3012 Bern, Switzerland 42.Russian Acad Sci, Inst Mol & Cellular Biol, Siberian Branch, Lab Human Mol Genet, Novosibirsk 630090, Russia 43.Univ Toulouse 3, CNRS UMR 5288, F-31000 Toulouse, France 44.North Eastern Fed Univ, Yakutsk 677013, Russia 45.Yakut Res Ctr Complex Med Problems, Yakutsk 677013, Russia 46.Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA 47.Univ Arizona, ARL Div Biotechnol, Tucson, AZ 85721 USA 48.SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA 49.Univ Bergen, Dept Clin Sci, N-5021 Bergen, Norway 50.Illumina, NextBio, Santa Clara, CA 95050 USA 51.Med Univ Sofia, Natl Human Genome Ctr, Dept Med Genet, Sofia 1431, Bulgaria 52.Russian Acad Sci, Ufa Res Ctr, Inst Biochem & Genet, Ufa 450054, Russia 53.Bashkir State Univ, Dept Genet & Fundamental Med, Ufa 450074, Russia 54.Univ Arizona, Coll Med, Tucson, AZ 85724 USA 55.Univ Cambridge, Div Biol Anthropol, Cambridge CB2 1QH, England 56.Vilnius State Univ, Dept Human & Med Genet, LT-08661 Vilnius, Lithuania 57.Estonian Bioctr, Evolutionary Biol Grp, EE-51010 Tartu, Estonia 58.Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France 59.UCL, Dept Genet Evolut & Environm, London WC1E 6BT, England 60.Gladstone Inst, San Francisco, CA 94158 USA 61.Univ Tartu, Dept Evolutionary Biol, EE-51010 Tartu, Estonia 62.Ctr Invest Biomed Guatemala, Guatemala City, Guatemala 63.23andMe, Res Dept, Mountain View, CA 94043 USA 64.Univ Oulu, Cultural Anthropol Program, Oulu 90014, Finland 65.Muhimbili Univ Hlth & Allied Sci, Dept Biochem, Dar Es Salaam 65001, Tanzania 66.North Eastern Fed Univ, Res Inst Hlth, Yakutsk 677000, Russia 67.Univ Palermo, Dipartimento Fis & Chim, I-90128 Palermo, Italy 68.Univ Tarapaca, Inst Alta Invest, Arica 1000000, Chile 69.Univ Chile, Fac Med, Programa Genet Humana, ICBM, Santiago 8320000, Chile 70.Ctr Invest Hombre Desierto, Arica 1000000, Chile 71.Univ Edinburgh, Sch Med, Ctr Populat Hlth Sci, Edinburgh EH8 9AG, Midlothian, Scotland 72.Uzbek Acad Sci, Inst Immunol, Tashkent 70000, Uzbekistan 73.Natl Acad Sci Armenia, Inst Mol Biol, Lab Ethnogenom, Yerevan 0014, Armenia 74.Univ Helsinki, Dept Forens Med, Hjelt Inst, Helsinki 00014, Finland 75.Univ North Texas Hlth Sci Ctr, Dept Mol & Med Genet, Inst Appl Genet, Ft Worth, TX 76107 USA 76.Univ Santiago de Compostela, Fac Med, GMX, Dept Anat Patol & Ciencias Forenses,Unidade Xenet, Galcia 15872, Spain 77.Univ Santiago de Compostela, Fac Med, GMX, Inst Ciencias Forenses, Galcia 15872, Spain 78.Henry Stewart Grp, London WC1A 2HN, England 79.Acad Sci Uzbek, Inst Bioorgan Chem, Tashkent 100125, Uzbekistan 80.Kharkov Natl Univ, Dept Genet & Cytol, UA-61077 Kharkov, Ukraine 81.Univ Mayor San Andres, Inst Boliviano Biol Altura, La Paz 5912, Bolivia 82.Univ Autonoma Tomas Frias, Potosi, Bolivia 83.Russian Acad Med Sci, Siberian Branch, Inst Internal Med, Novosibirsk 630089, Russia 84.Novosibirsk State Univ, Novosibirsk 630090, Russia 85.NCI, Basic Res Lab, NIH, Frederick Natl Lab,Leidos Biomed, Frederick, MD 21702 USA 86.Lebanese Amer Univ, Sch Med, Beirut 135053, Lebanon 87.Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA 88.Univ Split, Sch Med, Dept Med Biol, Split 21000, Croatia 89.Univ Penn, Dept Biol & Genet, Philadelphia, PA 19104 USA 90.CSIR Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India 91.Estonian Acad Sci, EE-10130 Tallinn, Estonia 92.Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Inst Biol Evolut CSIC UPF, Barcelona 08003, Spain 93.Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA 94.Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA 95.Univ Tubingen, Senckenberg Ctr Human Evolut & Palaeoenvironm, D-72070 Tubingen, Germany 96.Max Planck Inst Geschichte & Nat Wissensch, D-07745 Jena, Germany |
| 推荐引用方式 GB/T 7714 | Lazaridis, Iosif,Patterson, Nick,Mittnik, Alissa,et al. Ancient human genomes suggest three ancestral populations for present-day Europeans[J]. NATURE,2014,513(7518):409-+. |
| APA | Lazaridis, Iosif.,Patterson, Nick.,Mittnik, Alissa.,Renaud, Gabriel.,Mallick, Swapan.,...&Krause, Johannes.(2014).Ancient human genomes suggest three ancestral populations for present-day Europeans.NATURE,513(7518),409-+. |
| MLA | Lazaridis, Iosif,et al."Ancient human genomes suggest three ancestral populations for present-day Europeans".NATURE 513.7518(2014):409-+. |
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| lazaridis2014.pdf（7972KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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