IVPP-IR  > 中科院古脊椎所(2000年以后)
A high-coverage Neandertal genome from Vindija Cave in Croatia
Pruefer, Kay1; de Filippo, Cesare1; Grote, Steffi1; Mafessoni, Fabrizio1; Korlevic, Petra1; Hajdinjak, Mateja1; Vernot, Benjamin1; Skov, Laurits2; Hsieh, Pinghsun3; Peyregne, Stephane1; Reher, David1; Hopfe, Charlotte1; Nagel, Sarah1; Maricic, Tomislav1; Fu, Qiaomei4; Theunert, Christoph1; Rogers, Rebekah; Skoglund, Pontus5; Chintalapati, Manjusha1; Dannemann, Michael1; Nelson, Bradley J.3; Key, Felix M.1; Rudan, Pavao6; Kucan, Zeljko6; Gusic, Ivan6; Golovanova, Liubov V.7; Doronichev, Vladimir B.7; Patterson, Nick5; Reich, David5,9,10; Eichler, Evan E.3,11; Slatkin, Montgomery8; Schierup, Mikkel H.2; Andres, Aida M.1; Kelso, Janet1; Meyer, Matthias1; Paabo, Svante1
2017-11-03
发表期刊SCIENCE
卷号358期号:6363页码:655-658
文章类型Article
摘要To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from similar to 50,000 years ago from Vindija Cave, Croatia, to similar to 30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
WOS标题词Science & Technology
DOI10.1126/science.aao1887
关键词[WOS]MODERN HUMANS ; ADMIXTURE ; SEQUENCE ; ANCIENT ; DNA ; INTROGRESSION ; POPULATIONS ; ANCESTRY
收录类别SCI
语种英语
项目资助者National Key R&D Program of China(2016YFE0203700) ; Chinese Academy of Sciences(XDB13000000 ; National Natural Science Foundation of China(91731303 ; Howard Hughes Medical Institute(55008731) ; U.S. National Science Foundation(BCS-1032255) ; investigator of the Howard Hughes Medical Institute ; U.S. National Institutes of Health(NIH R01HGO02385) ; European Research Council(694707) ; Max Planck Foundation(31-12LMP Paabo) ; QYZDB-SS W-DQCO03 ; 41672021 ; XDPB05) ; 41630102)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000414240500039
引用统计
文献类型期刊论文
条目标识符http://119.78.100.205/handle/311034/7978
专题中科院古脊椎所(2000年以后)
作者单位1.Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
2.Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark
3.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
4.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China
5.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
6.Croatian Acad Sci & Arts, Anthropol Ctr, Zagreb 10000, Croatia
7.ANO Lab Prehist 14 Linia 3 11, St Petersburg 199034, Russia
8.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA
9.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA
10.Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA
11.Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA
推荐引用方式
GB/T 7714
Pruefer, Kay,de Filippo, Cesare,Grote, Steffi,et al. A high-coverage Neandertal genome from Vindija Cave in Croatia[J]. SCIENCE,2017,358(6363):655-658.
APA Pruefer, Kay.,de Filippo, Cesare.,Grote, Steffi.,Mafessoni, Fabrizio.,Korlevic, Petra.,...&Paabo, Svante.(2017).A high-coverage Neandertal genome from Vindija Cave in Croatia.SCIENCE,358(6363),655-658.
MLA Pruefer, Kay,et al."A high-coverage Neandertal genome from Vindija Cave in Croatia".SCIENCE 358.6363(2017):655-658.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
10.1126@science.aao1(1046KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Pruefer, Kay]的文章
[de Filippo, Cesare]的文章
[Grote, Steffi]的文章
百度学术
百度学术中相似的文章
[Pruefer, Kay]的文章
[de Filippo, Cesare]的文章
[Grote, Steffi]的文章
必应学术
必应学术中相似的文章
[Pruefer, Kay]的文章
[de Filippo, Cesare]的文章
[Grote, Steffi]的文章
相关权益政策
中科院和国家自然科学...
收藏/分享
文件名: 10.1126@science.aao1887.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。