Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout

doi:10.1038/s10038-017-0368-9

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	Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout
	Tu, Hung-Pin 1,2; Ko, Albert Min-Shan 3; Lee, Su-Shin 4; Lee, Chi-Pin 5; Kuo, Tzer-Min 5; Huang, Chung-Ming 6,7; Ko, Ying-Chin 5
	2018
发表期刊	JOURNAL OF HUMAN GENETICS
ISSN	1434-5161
卷号	63 期号:1 页码:63-70
文章类型	Article
摘要	We investigated the interactions of ALPK1 variants and the loci of ABCG2, SLC2A9, and SLC22A12 on gout risk. We conducted two case-control studies. Participants were recruited from hospitals (n = 410; 104 gout cases and 306 controls) and communities (n = 678; 373 gout cases and 305 controls) in Taiwan. The genotypes of ALPK1 (rs11726117 M861T, rs231247 R1084R, and rs231253 3' UTR), ABCG2 (rs2231142 Q141K and rs2231137 V12M), SLC2A9 (rs3733591 R265H and rs1014290), and SLC22A12 (rs3825016 H86H, rs11231825 H142H, and rs475688) were genotyped. Under a recessive model, the joint effects of ALPK1 variants and the SNPs rs2231142 of ABCG2, rs1014290 of SLC2A9, or rs475688 and rs3825016 of SLC22A12 were associated with gout. The rs11726117 [CC] of ALPK1 and rs2231142 [TT] of ABCG2 with the sequential addition of the rs1014290 [AA] of SLC2A9 and rs3825016 [CC] of SLC22A12 were associated with gout risk (odds ratio (OR): 13.01, 15.11, and 55.00 and positive predictive value (PPV): 56%, 69%, and 99% in the Han group, respectively; OR: 3.76, 5.78, and 12.30 and PPV: 74%, 80%, and 81% in the aboriginal group, respectively). Combined exposure to the four high-risk genotypes of ALPK1 and the uric-acid-related loci of ABCG2, SLC2A9, and SLC22A12 was associated with an increased gout risk and a high PPV for gout.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1038/s10038-017-0368-9
关键词[WOS]	GENOME-WIDE ASSOCIATION ; URIC-ACID ; MOLECULAR PHYSIOLOGY ; HYPERURICEMIA ; RISK ; POPULATION ; IDENTIFICATION ; EXCRETION ; ARTHRITIS ; LOCI
收录类别	SCI
语种	英语
项目资助者	Ministry of Science and Technology(MOST 105-2632-B-039-001 ; China Medical University(CMU105-S-01 ; Kaohsiung Medical University Research Foundation(KMU-M106006) ; MOST 106-2314-B-037-034) ; CMU105-S-03 ; CMU105-S-04 ; CMU105-S-06 ; DMR-106-115)
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000419977800008
出版者	NATURE PUBLISHING GROUP
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/8714
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Ko, Ying-Chin
作者单位	1.Kaohsiung Med Univ, Coll Med, Sch Med, Dept Publ Hlth & Environm Med, Kaohsiung, Taiwan 2.Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan 3.Chinese Acad Sci, IVPP, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 4.Kaohsiung Med Univ Hosp, Dept Surg, Div Plast Surg, Kaohsiung, Taiwan 5.China Med Univ, China Med Univ Hosp, Environment Omics Dis Res Ctr, Taichung 40402, Taiwan 6.China Med Univ Hosp, Dept Internal Med, Div Rheumatol & Immunol, Taichung 404, Taiwan 7.China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan
推荐引用方式 GB/T 7714	Tu, Hung-Pin,Ko, Albert Min-Shan,Lee, Su-Shin,et al. Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout[J]. JOURNAL OF HUMAN GENETICS,2018,63(1):63-70.
APA	Tu, Hung-Pin.,Ko, Albert Min-Shan.,Lee, Su-Shin.,Lee, Chi-Pin.,Kuo, Tzer-Min.,...&Ko, Ying-Chin.(2018).Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout.JOURNAL OF HUMAN GENETICS,63(1),63-70.
MLA	Tu, Hung-Pin,et al."Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout".JOURNAL OF HUMAN GENETICS 63.1(2018):63-70.

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