The evolutionary history of Neanderthal and Denisovan Y chromosomes

doi:10.1126/science.abb6460

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	The evolutionary history of Neanderthal and Denisovan Y chromosomes
	Petr, Martin 1; Hajdinjak, Mateja 1,2; Fu, Qiaomei3,4,5 ; Essel, Elena 1; Rougier, Helene 6; Crevecoeur, Isabelle 7; Semal, Patrick 8; Golovanova, Liubov, V 9; Doronichev, Vladimir B.9; Lalueza-Fox, Carles 10; de la Rasilla, Marco 11; Rosas, Antonio 12; Shunkov, Michael, V 13; Kozlikin, Maxim B.13; Derevianko, Anatoli P.13; Vernot, Benjamin 1; Meyer, Matthias 1; Kelso, Janet 1
	2020-09-25
发表期刊	SCIENCE
ISSN	0036-8075
卷号	369 期号:6511 页码:1653-+
摘要	Ancient DNA has provided new insights into many aspects of human history. However, we lack comprehensive studies of the Y chromosomes of Denisovans and Neanderthals because the majority of specimens that have been sequenced to sufficient coverage are female. Sequencing Y chromosomes from two Denisovans and three Neanderthals shows that the Y chromosomes of Denisovans split around 700 thousand years ago from a lineage shared by Neanderthals and modern human Y chromosomes, which diverged from each other around 370 thousand years ago. The phylogenetic relationships of archaic and modern human Y chromosomes differ from the population relationships inferred from the autosomal genomes and mirror mitochondrial DNA phylogenies, indicating replacement of both the mitochondrial and Y chromosomal gene pools in late Neanderthals. This replacement is plausible if the low effective population size of Neanderthals resulted in an increased genetic load in Neanderthals relative to modern humans.
DOI	10.1126/science.abb6460
关键词[WOS]	GENOME SEQUENCE ; DNA-SEQUENCES ; ANCIENT BONES ; GENE FLOW ; MITOCHONDRIAL ; CAVE ; PATTERNS ; PHYLOGENY
收录类别	SCI
语种	英语
资助项目	Max Planck Society ; National Natural Science Foundation of China[41630102] ; Chinese Academy of Sciences[XDB26000000] ; National Natural Science Foundation of China[91731303] ; National Natural Science Foundation of China[41925009] ; Spanish government (MICINN/FEDER)[CGL2016-75109-P] ; Belgian Science Policy Office (BELSPO)[MO/36/0112] ; Russian Foundation for Basic Research[RFBR 17-29-04206] ; European Research Council[694707]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000574653300040
出版者	AMER ASSOC ADVANCEMENT SCIENCE
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/18114
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Petr, Martin; Kelso, Janet
作者单位	1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 2.Francis Crick Inst, London NW1 1AT, England 3.Chinese Acad Sci, CAS, IVPP, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 4.CAS Ctr Excellence Life & Paleoenvironm, Beijing 100044, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Calif State Univ Northridge, Dept Anthropol, Northridge, CA 91330 USA 7.Univ Bordeaux, CNRS, UMR PACEA 5199, F-33615 Pessac, France 8.Royal Belgian Inst Nat Sci, B-1000 Brussels, Belgium 9.ANO Lab Prehist 14 Linia 3 11, St Petersburg 199034, Russia 10.Univ Pompeu Fabra, Inst Evolutionary Biol, CSIC, Barcelona 08003, Spain 11.Univ Oviedo, Dept Hist, Area Prehist, Oviedo 33011, Spain 12.CSIC, Museo Nacl Ciencias Nat, Dept Paleobiol, Madrid 28006, Spain 13.Russian Acad Sci, Inst Archaeol & Ethnog, Siberian Branch, Novosibirsk, Russia
推荐引用方式 GB/T 7714	Petr, Martin,Hajdinjak, Mateja,Fu, Qiaomei,et al. The evolutionary history of Neanderthal and Denisovan Y chromosomes[J]. SCIENCE,2020,369(6511):1653-+.
APA	Petr, Martin.,Hajdinjak, Mateja.,Fu, Qiaomei.,Essel, Elena.,Rougier, Helene.,...&Kelso, Janet.(2020).The evolutionary history of Neanderthal and Denisovan Y chromosomes.SCIENCE,369(6511),1653-+.
MLA	Petr, Martin,et al."The evolutionary history of Neanderthal and Denisovan Y chromosomes".SCIENCE 369.6511(2020):1653-+.

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