Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium

doi:10.1016/j.cell.2025.05.040

IVPP-IR

	Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium
	Fu, Qiaomei1,2 ; Cao, Peng 1; Dai, Qingyan 1; Bennett, E. Andrew 1; Feng, Xiaotian 1; Yang, Melinda A.3; Ping, Wanjing 1; Paabo, Svante 4; Ji, Qiang 5
	2025-07-24
发表期刊	CELL
ISSN	0092-8674
卷号	188 期号:15 页码:3919-3926
通讯作者	Fu, Qiaomei(fuqiaomei@ivpp.ac.cn)
摘要	Denisovans have yet to be directly associated with a hominin cranium, limiting our understanding of their morphology and geographical distribution. We have attempted to retrieve DNA from a nearly complete Middle Pleistocene cranium from Harbin (>146 ka), northeastern China. Although no DNA could be retrieved from a tooth or the petrous bone, mitochondrial DNA (mtDNA) could be isolated from dental calculus. The mtDNA falls within Denisovan mtDNA variation and is related to an mtDNA branch carried by early Denisovan individuals in southern Siberia, previously observed in Denisova Cave. This suggests that Denisovans inhabited a large geographical range in Asia in the Middle Pleistocene. The association of Denisovan mtDNA with the Harbin cranium allows a better understanding of the morphological relationships between Denisovans and other East Asian Middle Pleistocene fossils. Furthermore, the retrieval of host DNA from dental calculus opens new possibilities for genetic research on Middle Pleistocene hominins.
DOI	10.1016/j.cell.2025.05.040
关键词[WOS]	GENOME SEQUENCE ; GENETIC HISTORY ; ANCIENT ; NEANDERTHAL ; CAVE ; HOMININ ; ENRICHMENT ; ASIA
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41842039] ; Chinese Academy of Sciences of China (CAS)[YSBR-019]
项目资助者	National Natural Science Foundation of China ; Chinese Academy of Sciences of China (CAS)
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:001543361000002
出版者	CELL PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/24815
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Fu, Qiaomei
作者单位	1.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China 3.Univ Richmond, Dept Biol, Richmond, VA 23173 USA 4.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 5.Hebei GEO Univ, Coll Earth Sci, Hebei Int Joint Res Ctr Paleoanthropol, Shijiazhuang 050031, Peoples R China
推荐引用方式 GB/T 7714	Fu, Qiaomei,Cao, Peng,Dai, Qingyan,et al. Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium[J]. CELL,2025,188(15):3919-3926.
APA	Fu, Qiaomei.,Cao, Peng.,Dai, Qingyan.,Bennett, E. Andrew.,Feng, Xiaotian.,...&Ji, Qiang.(2025).Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium.CELL,188(15),3919-3926.
MLA	Fu, Qiaomei,et al."Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium".CELL 188.15(2025):3919-3926.