An early East Asian lineage with unexpectedly low Denisovan ancestry

doi:10.1016/j.cub.2025.08.051

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	An early East Asian lineage with unexpectedly low Denisovan ancestry
	Yang, Jiaqi 1; Iasi, Leonardo N. M.1; Fu, Qiaomei2 ; Kelso, Janet 1; Cooke, Niall P.1; Peyregne, Stephane 1; Peter, Benjamin M.1,2,3
	2025-10-20
发表期刊	CURRENT BIOLOGY
ISSN	0960-9822
卷号	35 期号:20 页码:4898-4908
通讯作者	Peter, Benjamin M.(benjamin_peter@eva.mpg.de)
摘要	Denisovan ancestry in present-day humans is heterogeneously distributed and comes from genetically distinct Denisovan groups. Understanding the origin of this heterogeneity could provide insights into the early population history of modern humans in Eurasia. However, population movements and admixture after the initial dispersals of modern humans have obscured the origin of this heterogeneity. To address this, we investigated how Denisovan ancestry in early modern humans relates to that in present-day humans. We found that varying levels of Denisovan ancestry in Eurasians were shaped by admixture between diverse early modern human lineages. In particular, ancient Japanese individuals from the Jomon period have the least Denisovan ancestry among individuals from Eastern Eurasia, providing evidence for an ancient East Asian lineage with little to no Denisovan ancestry. By contrast, the earliest mainland East Asians harbor the most Denisovan ancestry in Eastern Eurasia, including ancestry from multiple divergent Denisovan groups, already before the last glacial maximum. Together with evidence of Denisovan ancestry sharing among ancient and present-day genomes, these patterns show how Denisovan ancestry in Eurasia spread through gene flow from early East Asians. Our study provides the first systematic investigation of Denisovan admixture across time and extends our understanding of human population history in Eurasia.
DOI	10.1016/j.cub.2025.08.051
关键词[WOS]	COVERAGE NEANDERTHAL GENOME ; POPULATION HISTORY ; LATE PLEISTOCENE ; DNA ; CAVE ; NORTHERN ; SEQUENCE ; LANDSCAPE ; DIVERSITY ; ADMIXTURE
收录类别	SCI
语种	英语
资助项目	Max Planck Society###39 ; European Research Council[1010424210]###3554
项目资助者	Max Planck Society ; European Research Council
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS记录号	WOS:001604698100014
出版者	CELL PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/25103
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Peter, Benjamin M.
作者单位	1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 2.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100049, Peoples R China 3.Univ Rochester, Dept Biol, Rochester, NY 14620 USA
推荐引用方式 GB/T 7714	Yang, Jiaqi,Iasi, Leonardo N. M.,Fu, Qiaomei,et al. An early East Asian lineage with unexpectedly low Denisovan ancestry[J]. CURRENT BIOLOGY,2025,35(20):4898-4908.
APA	Yang, Jiaqi.,Iasi, Leonardo N. M..,Fu, Qiaomei.,Kelso, Janet.,Cooke, Niall P..,...&Peter, Benjamin M..(2025).An early East Asian lineage with unexpectedly low Denisovan ancestry.CURRENT BIOLOGY,35(20),4898-4908.
MLA	Yang, Jiaqi,et al."An early East Asian lineage with unexpectedly low Denisovan ancestry".CURRENT BIOLOGY 35.20(2025):4898-4908.