Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status

doi:10.1016/j.cell.2025.10.016

IVPP-IR

	Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status
	Wang, Sheng 1; Chen, Zehui 2; Luo, Ayun 1,3; You, Xinran 1; Kitchener, Andrew C.4,5; Tu, Xiaolong 1,3; Thakur, Mukesh 6; Umapathy, Govindhaswamy 7; Hu, Songmei 8,9; Zhang, Tianen 10; Zhang, Yingqi 2; Liu, Siqiong 2,3; Ding, Yan 10; Liu, Feng 2; Dai, Qingyan 2; Feng, Xiaotian 2; Li, Lei 11; Pan, Yue 2; Zhang, Ming 12; Roos, Christian 13,14; Fan, Pengfei 15; Fu, Qiaomei2,3 ; Wu, Dong-Dong 1,16,17
	2026-01-08
发表期刊	CELL
ISSN	0092-8674
卷号	189 期号:1 页码:39
通讯作者	Fan, Pengfei(fanpf@mail.sysu.edu.cn) ; Fu, Qiaomei(fuqiaomei@ivpp.ac.cn) ; Wu, Dong-Dong(wudongdong@mail.kiz.ac.cn)
摘要	Gibbons (family Hylobatidae), small apes closely related to humans and great apes, remain understudied despite their threatened status. Here, we present extensive genomic resources, including chromosome-level reference genomes, whole-genome resequencing of 18 extant species, and mitochondrial genomes from 3 ancient samples. Using whole-genome alignments, we resolve the debated phylogeny of the four genera as (Hylobates, (Nomascus, (Symphalangus, Hoolock))). Phylogenetic analyses based on the ancient mitogenomes place the extinct Junzi imperialis within Nomascus, refuting its status as a distinct genus. Conservation genomics and ecological niche modeling analyses suggest historical dynamics in gibbon population size and habitat suitability, which are consistent with the potential impacts of past climate change. Through comparative genomics and transgenic mouse experiments, we identify a 205-bp deletion in the Sonic Hedgehog (SHH) gene associated with gibbons' elongated limbs. These findings advance understanding of gibbon evolution, biology, and conservation.
DOI	10.1016/j.cell.2025.10.016
关键词[WOS]	STRUCTURAL VARIATION ; TOOL ; EVOLUTION ; ALIGNMENT ; COLLECTION ; PREDICTION ; DIVERSITY ; INSIGHTS ; DATABASE ; PROGRAM
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program[2022YFF1301500]###3590 ; National Natural Science Foundation of China[41925009]###844 ; National Natural Science Foundation of China[32100489]###3027 ; Chinese Academy of Sciences (CAS) Light of West China Program[XBZG-ZDSYS-202213]###3591 ; Chinese Academy of Sciences (CAS)[YSBR-019]###1748 ; Youth Innovation Promotion Association CAS###201 ; Yunnan Provincial Department of Science and Technology[202305AH340006]###3592 ; Yunnan Revitalization Talent Support Program Yunling Scholar Project###3593 ; Yunnan Revitalization Talent Support Program Young Talent Project###3594
项目资助者	National Key Research and Development Program ; National Natural Science Foundation of China ; Chinese Academy of Sciences (CAS) Light of West China Program ; Chinese Academy of Sciences (CAS) ; Youth Innovation Promotion Association CAS ; Yunnan Provincial Department of Science and Technology ; Yunnan Revitalization Talent Support Program Yunling Scholar Project ; Yunnan Revitalization Talent Support Program Young Talent Project
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:001666246200001
出版者	CELL PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/25205
专题	中国科学院古脊椎动物与古人类研究所
通讯作者	Fan, Pengfei; Fu, Qiaomei; Wu, Dong-Dong
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Evolut & Anim Models, Kunming Nat Hist Museum Zool, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Natl Museums Scotland, Dept Nat Sci, Chambers St, Edinburgh EH1 1JF, Scotland 5.Univ Edinburgh, Sch Geosci, Drummond St, Edinburgh EH9 3PX, Scotland 6.Zool Survey India, Kolkata 700053, W Bengal, India 7.CSIR Ctr Cellular & Mol Biol, Lab Conservat Endangered Species, Uppal Rd, Hyderabad 500007, India 8.Shandong Univ, Key Lab Archaeol Sci & Technol, Minist Educ, Qingdao 266237, Peoples R China 9.Shandong Univ, Inst Cultural Heritage, Qingdao 266237, Peoples R China 10.Shaanxi Acad Archaeol, Xian 710054, Peoples R China 11.Chongqing China Three Gorges Museum, Chongqing 400015, Peoples R China 12.Northwest Univ, Sch Cultural Heritage, Xian 710069, Peoples R China 13.German Primate Ctr, Leibniz Inst Primate Res, Primate Genet Lab, Gottingen, Germany 14.German Primate Ctr, Leibniz Inst Primate Res, Gene Bank Primates, Gottingen, Germany 15.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Peoples R China 16.Chinese Acad Sci, Kunming Inst Zool, Natl Resource Ctr Nonhuman Primates, Kunming Primate Res Ctr, Kunming 650107, Yunnan, Peoples R China 17.Chinese Acad Sci, Kunming Inst Zool, Natl Res Facil Phenotyp & Genet Anal Model Anim Pr, Kunming 650107, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wang, Sheng,Chen, Zehui,Luo, Ayun,et al. Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status[J]. CELL,2026,189(1):39.
APA	Wang, Sheng.,Chen, Zehui.,Luo, Ayun.,You, Xinran.,Kitchener, Andrew C..,...&Wu, Dong-Dong.(2026).Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status.CELL,189(1),39.
MLA	Wang, Sheng,et al."Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status".CELL 189.1(2026):39.