KMS Institute of Vertebrate Paleontology and Paleoanthropology
| TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates | |
| Zhao Min1,2; Chen YanMing3; Qu DaCheng3; Qu Hong1; quh@mail.cbi.pku.edu.cn | |
| 2011 | |
| 发表期刊 | SCIENCE CHINA-LIFE SCIENCES
 |
| ISSN | 1674-7305 |
| 卷号 | 54期号:1页码:60-64 |
| 文章类型 | Article |
| 摘要 | TSdb (http://tsdb.cbi.pku.edu.cn) is the first manually curated central repository that stores formatted information on the substrates of transporters. In total, 37608 transporters with 15075 substrates from 884 organisms were curated from UniProt functional annotation. A unique feature of TSdb is that all the substrates are mapped to identifiers from the KEGG Ligand compound database. Thus, TSdb links current metabolic pathway schema with compound transporter systems via the shared compounds in the pathways. Furthermore, all the transporter substrates in TSdb are classified according to their biochemical properties, biological roles and subcellular localizations. In addition to the functional annotation of transporters, extensive compound annotation that includes inhibitor information from the KEGG Ligand and BRENDA databases has been integrated, making TSdb a useful source for the discovery of potential inhibitory mechanisms linking transporter substrates and metabolic enzymes. User-friendly web interfaces are designed for easy access, query and download of the data. Text and BLAST searches against all transporters in the database are provided. We will regularly update the substrate data with evidence from new publications. |
| 关键词 | Transporter Substrate Biological Database Compound Classification Compound Metabolic Network |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| URL | 查看原文 |
| 关键词[WOS] | RELATIONAL DATABASE ; RESOURCE ; KEGG ; PHARMACOGENOMICS ; INFORMATION ; UPDATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| WOS记录号 | WOS:000286470400009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/4481 |
| 专题 | 中科院古脊椎所（2000年以后） |
| 通讯作者 | quh@mail.cbi.pku.edu.cn |
| 作者单位 | 1.Peking Univ, Ctr Bioinformat, Natl Lab Prot Engn & Plant Genet Engn, Coll Life Sci, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Key Lab Evolutionary Systemat Vertebrates, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 3.Beijing Inst Technol, Sch Comp Sci & Technol, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao Min,Chen YanMing,Qu DaCheng,et al. TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(1):60-64. |
| APA | Zhao Min,Chen YanMing,Qu DaCheng,Qu Hong,&quh@mail.cbi.pku.edu.cn.(2011).TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates.SCIENCE CHINA-LIFE SCIENCES,54(1),60-64. |
| MLA | Zhao Min,et al."TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates".SCIENCE CHINA-LIFE SCIENCES 54.1(2011):60-64. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| TSdb A database of t（1375KB） | 开放获取 | -- | 浏览 下载 | |||
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