| Replaying evolutionary transitions from the dental fossil record | |
| Harjunmaa, Enni1; Seidel, Kerstin2,3; Hakkinen, Teemu1; Renvoise, Elodie1; Corfe, Ian J.1; Kallonen, Aki4; Zhang, Zhao-Qun5; Evans, Alistair R.6,7; Mikkola, Marja L.1; Salazar-Ciudad, Isaac1,8; Klein, Ophir D.2,3,9,10; Jernvall, Jukka1; Jernvall, J (reprint author), Univ Helsinki, Inst Biotechnol, Dev Biol Program, POB 56, FIN-00014 Helsinki, Finland. | |
| 2014-08-07 | |
| 发表期刊 | NATURE
 |
| ISSN | 0028-0836 |
| 卷号 | 512期号:7512页码:44-+ |
| 文章类型 | Article |
| 摘要 | The evolutionary relationships of extinct species are ascertained primarily through the analysis of morphological characters. Character inter-dependencies can have a substantial effect on evolutionary interpretations, but the developmental underpinnings of character inter-dependence remain obscure because experiments frequently do not provide detailed resolution of morphological characters. Here we show experimentally and computationally how gradual modification of development differentially affects characters in the mouse dentition. We found that intermediate phenotypes could be produced by gradually adding ectodysplas in A (EDA) protein in culture to tooth explants carrying a null mutation in the tooth-patterning gene Eda. By identifying development-based character inter-dependencies, we show how to predict morphological patterns of teeth among mammalian species. Finally, in vivo inhibition of sonic hedgehog signalling in Eda null teeth enabled us to reproduce characters deep in the rodent ancestry. Taken together, evolutionarily informative transitions can be experimentally reproduced, thereby providing development-based expectations for character-state transitions used in evolutionary studies. |
| WOS标题词 | Science & Technology |
| 关键词[WOS] | TRIBOSPHENIC MAMMALS ; ECTODERMAL DYSPLASIA ; GENE-EXPRESSION ; TEETH ; PATTERNS ; ECTODYSPLASIN ; CHARACTERS ; MOLECULES ; RADIATION ; DYNAMICS |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | Academy of Finland; NIH/NIDCR [R01-DE021420]; NIH [DP2-OD007191]; Australian Research Council; MST [2012CB821904] |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000339908000027 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/5139 |
| 专题 | 古哺乳动物研究室 |
| 通讯作者 | Jernvall, J (reprint author), Univ Helsinki, Inst Biotechnol, Dev Biol Program, POB 56, FIN-00014 Helsinki, Finland. |
| 作者单位 | 1.Univ Helsinki, Inst Biotechnol, Dev Biol Program, FIN-00014 Helsinki, Finland 2.Univ Calif San Francisco, Program Craniofacial & Mesenchymal Biol, San Francisco, CA 94114 USA 3.Univ Calif San Francisco, Dept Orofacial Sci, San Francisco, CA 94114 USA 4.Univ Helsinki, Dept Phys, Div Mat Phys, FIN-00014 Helsinki, Finland 5.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Evolutionary Systemat Vertebrates, Beijing 100044, Peoples R China 6.Monash Univ, Sch Biol Sci, Clayton, Vic 3800, Australia 7.Museum Victoria, Melbourne, Vic 3001, Australia 8.Univ Autonoma Barcelona, Dept Genet & Microbiol, Genom Bioinformat & Evolut Group, Cerdanyola Del Valles 08193, Spain 9.Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94114 USA 10.Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94114 USA |
| 推荐引用方式 GB/T 7714 | Harjunmaa, Enni,Seidel, Kerstin,Hakkinen, Teemu,et al. Replaying evolutionary transitions from the dental fossil record[J]. NATURE,2014,512(7512):44-+. |
| APA | Harjunmaa, Enni.,Seidel, Kerstin.,Hakkinen, Teemu.,Renvoise, Elodie.,Corfe, Ian J..,...&Jernvall, J .(2014).Replaying evolutionary transitions from the dental fossil record.NATURE,512(7512),44-+. |
| MLA | Harjunmaa, Enni,et al."Replaying evolutionary transitions from the dental fossil record".NATURE 512.7512(2014):44-+. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Replaying evolutiona（1948KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论