| Patterns of coding variation in the complete exomes of three Neandertals | |
| Castellano, Sergi1; Parra, Genis1; Sanchez-Quinto, Federico A.2; Racimo, Fernando1,3; Kuhlwilm, Martin1; Kircher, Martin1,4; Sawyer, Susanna1; Fu, Qiaomei1,5; Heinze, Anja1; Nickel, Birgit1; Dabney, Jesse1; Siebauer, Michael1; White, Louise1; Burbano, Hernan A.1,6; Renaud, Gabriel1; Stenzel, Udo1; Lalueza-Fox, Carles2; de la Rasilla, Marco7; Rosas, Antonio8; Rudan, Pavao9; Brajkovic, Dejana10; Kucan, Zeljko9; Gusic, Ivan10; Shunkov, Michael V.11; Derevianko, Anatoli P.11; Viola, Bence1,12; Meyer, Matthias1; Kelso, Janet1; Andres, Aida M.1; Paeaebo, Svante1; Castellano, S (reprint author), Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany. | |
| 2014-05-06 | |
| 发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| ISSN | 0027-8424 |
| 卷号 | 111期号:18页码:6666-6671 |
| 文章类型 | Article |
| 摘要 | We present the DNA sequence of 17,367 protein-coding genes in two Neandertals from Spain and Croatia and analyze them together with the genome sequence recently determined from a Neandertal from southern Siberia. Comparisons with present-day humans from Africa, Europe, and Asia reveal that genetic diversity among Neandertals was remarkably low, and that they carried a higher proportion of amino acid-changing (nonsynonymous) alleles inferred to alter protein structure or function than present-day humans. Thus, Neandertals across Eurasia had a smaller long-term effective population than present-day humans. We also identify amino acid substitutions in Neandertals and present-day humans that may underlie phenotypic differences between the two groups. We find that genes involved in skeletal morphology have changed more in the lineage leading to Neandertals than in the ancestral lineage common to archaic and modern humans, whereas genes involved in behavior and pigmentation have changed more on the modern human lineage. |
| 关键词 | Ancient Dna Exome Capture Site Frequency Spectra Paleogenetics |
| WOS标题词 | Science & Technology |
| 关键词[WOS] | GENOME SEQUENCE ; ANCIENT DNA ; SELECTION ; GENES ; CAVE ; POPULATIONS ; EVOLUTION ; CAPTURE ; HISTORY |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | Max Planck Society; Ministerio de Economia y Competitividad [BFU2012-34157] |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000335477300045 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/5158 |
| 专题 | 古人类及旧石器研究室 |
| 通讯作者 | Castellano, S (reprint author), Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany. |
| 作者单位 | 1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 2.Univ Pompeu Fabra, Inst Evolutionary Biol, Consejo Super Invest Cient, Barcelona 08003, Spain 3.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 4.Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA 5.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Palaeontol & Palaeoanthropol, Beijing 100044, Peoples R China 6.Max Planck Inst Dev Biol, Dept Mol Biol, D-72076 Tubingen, Germany 7.Univ Oviedo, Area Prehist, Dept Hist, Oviedo 33011, Spain 8.CSIC, Dept Paleobiol, Museo Nacl Ciencias Nat, Madrid 28006, Spain 9.Croatian Acad Sci & Arts, Anthropol Ctr, HR-10000 Zagreb, Croatia 10.Croatian Acad Sci & Arts, Inst Quaternary Paleontol & Geol, HR-10000 Zagreb, Croatia 11.Russian Acad Sci, Inst Archeol & Ethnog, Siberian Branch, Paleolith Dept, Novosibirsk 630090, Russia 12.Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany |
| 推荐引用方式 GB/T 7714 | Castellano, Sergi,Parra, Genis,Sanchez-Quinto, Federico A.,et al. Patterns of coding variation in the complete exomes of three Neandertals[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014,111(18):6666-6671. |
| APA | Castellano, Sergi.,Parra, Genis.,Sanchez-Quinto, Federico A..,Racimo, Fernando.,Kuhlwilm, Martin.,...&Castellano, S .(2014).Patterns of coding variation in the complete exomes of three Neandertals.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(18),6666-6671. |
| MLA | Castellano, Sergi,et al."Patterns of coding variation in the complete exomes of three Neandertals".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.18(2014):6666-6671. |
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