KMS Institute of Vertebrate Paleontology and Paleoanthropology
| Genome sequence of a 45,000-year-old modern human from western Siberia | |
| Fu, Qiaomei1,2; Li, Heng3,4; Moorjani, Priya3,5; Jay, Flora6; Slepchenko, Sergey M.7; Bondarev, Aleksei A.8; Johnson, Philip L. F.9; Aximu-Petri, Ayinuer2; Pruefer, Kay2; de Filippo, Cesare2; Meyer, Matthias2; Zwyns, Nicolas10,11; Salazar-Garcia, Domingo C.10,12,13,14; Kuzmin, Yaroslav V.15; Keates, Susan G.15; Kosintsev, Pavel A.16; Razhev, Dmitry I.7; Richards, Michael P.10,17; Peristov, Nikolai V.18; Lachmann, Michael2,19; Douka, Katerina20; Higham, Thomas F. G.20; Slatkin, Montgomery6; Hublin, Jean-Jacques10; Reich, David3,4,21; Kelso, Janet2; Viola, T. Bence2,10; Paeaebo, Svante2 | |
| 2014-10-23 | |
| 发表期刊 | NATURE
 |
| 卷号 | 514期号:7523页码:445-+ |
| 文章类型 | Article |
| 摘要 | We present the high-quality genome sequence of a similar to 45,000-year-old modern human male from Siberia. This individual derives from a population that lived before-or simultaneously with-the separation of the populations in western and eastern Eurasia and carries a similar amount of Neanderthal ancestry as present-day Eurasians. However, the genomic segments of Neanderthal ancestry are substantially longer than those observed in present-day individuals, indicating that Neanderthal gene flow into the ancestors of this individual occurred 7,000-13,000 years before he lived. We estimate an autosomal mutation rate of 0.4 x 10(-9) to 0.6 x 10(-9) per site per year, a Y chromosomal mutation rate of 0.7 x 10(-9) to 0.9 x 10(-9) per site per year based on the additional substitutions that have occurred in present-day non-Africans compared to this genome, and a mitochondrial mutation rate of 1.8 x 10(-8) to 3.2 x 10(-8) per site per year based on the age of the bone. |
| WOS标题词 | Science & Technology |
| DOI | 10.1038/nature13810 |
| 关键词[WOS] | HUMAN-EVOLUTION ; HUMAN DISPERSALS ; HISTORY ; ASIA ; DIVERGENCE ; ADMIXTURE ; EUROPE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000343775900030 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.205/handle/311034/7377 |
| 专题 | 中科院古脊椎所（2000年以后） |
| 作者单位 | 1.Chinese Acad Sci, IVPP, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 2.Max Planck Inst Evolutionare Anthropol, Dept EvolutionaryGenet, D-04103 Leipzig, Germany 3.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA 4.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 5.Columbia Univ, Dept Biol Sci, New York, NY 10027 USA 6.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 7.Russian Acad Sci, Siberian Branch, Inst Problems Dev North, Tyumen 625026, Russia 8.Minist Internal Affairs, Omsk Div, Expert Criminalist Ctr, Omsk 644007, Russia 9.Emory Univ, Dept Biol, Atlanta, GA 30322 USA 10.Max Planck Inst Evolutionare Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany 11.Univ Calif Davis, Dept Anthropol, Davis, CA 95616 USA 12.Univ Cape Town, Dept Archaeol, ZA-7701 Cape Town, South Africa 13.Univ Valencia, Dept Prehist & Arqueol, Valencia 46010, Spain 14.Max Planck Inst Evolutionare Anthropol, Res Grp Plant Foods Hominin Dietary Ecol, D-04103 Leipzig, Germany 15.Russian Acad Sci, Siberian Branch, Inst Geol & Mineral, Novosibirsk 630090, Russia 16.Russian Acad Sci, Urals Branch, Inst Plant & Anim Ecol, Ekaterinburg 620144, Russia 17.Univ British Columbia, Dept Anthropol, Lab Archaeol, Vancouver, BC V6T 1Z1, Canada 18.Siberian Cultural Ctr, Omsk 644010, Russia 19.Santa Fe Inst, Santa Fe, NM 87501 USA 20.Univ Oxford, Res Lab Archaeol & Hist Art, Oxford Radiocarbon Accelerator Unit, Oxford OX1 3QY, England 21.Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Fu, Qiaomei,Li, Heng,Moorjani, Priya,et al. Genome sequence of a 45,000-year-old modern human from western Siberia[J]. NATURE,2014,514(7523):445-+. |
| APA | Fu, Qiaomei.,Li, Heng.,Moorjani, Priya.,Jay, Flora.,Slepchenko, Sergey M..,...&Paeaebo, Svante.(2014).Genome sequence of a 45,000-year-old modern human from western Siberia.NATURE,514(7523),445-+. |
| MLA | Fu, Qiaomei,et al."Genome sequence of a 45,000-year-old modern human from western Siberia".NATURE 514.7523(2014):445-+. |
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| fu2014.pdf（1199KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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