A high-coverage Neandertal genome from Vindija Cave in Croatia

doi:10.1126/science.aao1887

IVPP-IR > 中科院古脊椎所（2000年以后）

	A high-coverage Neandertal genome from Vindija Cave in Croatia
	Pruefer, Kay 1; de Filippo, Cesare 1; Grote, Steffi 1; Mafessoni, Fabrizio 1; Korlevic, Petra 1; Hajdinjak, Mateja 1; Vernot, Benjamin 1; Skov, Laurits 2; Hsieh, Pinghsun 3; Peyregne, Stephane 1; Reher, David 1; Hopfe, Charlotte 1; Nagel, Sarah 1; Maricic, Tomislav 1; Fu, Qiaomei 4; Theunert, Christoph 1; Rogers, Rebekah ; Skoglund, Pontus 5; Chintalapati, Manjusha 1; Dannemann, Michael 1; Nelson, Bradley J.3; Key, Felix M.1; Rudan, Pavao 6; Kucan, Zeljko 6; Gusic, Ivan 6; Golovanova, Liubov V.7; Doronichev, Vladimir B.7; Patterson, Nick 5; Reich, David 5,9,10; Eichler, Evan E.3,11; Slatkin, Montgomery 8; Schierup, Mikkel H.2; Andres, Aida M.1; Kelso, Janet 1; Meyer, Matthias 1; Paabo, Svante 1
	2017-11-03
发表期刊	SCIENCE
卷号	358 期号:6363 页码:655-658
文章类型	Article
摘要	To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from similar to 50,000 years ago from Vindija Cave, Croatia, to similar to 30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
WOS标题词	Science & Technology
DOI	10.1126/science.aao1887
关键词[WOS]	MODERN HUMANS ; ADMIXTURE ; SEQUENCE ; ANCIENT ; DNA ; INTROGRESSION ; POPULATIONS ; ANCESTRY
收录类别	SCI
语种	英语
项目资助者	National Key R&D Program of China(2016YFE0203700) ; Chinese Academy of Sciences(XDB13000000 ; National Natural Science Foundation of China(91731303 ; Howard Hughes Medical Institute(55008731) ; U.S. National Science Foundation(BCS-1032255) ; investigator of the Howard Hughes Medical Institute ; U.S. National Institutes of Health(NIH R01HGO02385) ; European Research Council(694707) ; Max Planck Foundation(31-12LMP Paabo) ; QYZDB-SS W-DQCO03 ; 41672021 ; XDPB05) ; 41630102)
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000414240500039
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.205/handle/311034/7958
专题	中科院古脊椎所（2000年以后）
作者单位	1.Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany 2.Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark 3.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA 4.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 5.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA 6.Croatian Acad Sci & Arts, Anthropol Ctr, Zagreb 10000, Croatia 7.ANO Lab Prehist 14 Linia 3 11, St Petersburg 199034, Russia 8.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 9.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA 10.Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA 11.Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA
推荐引用方式 GB/T 7714	Pruefer, Kay,de Filippo, Cesare,Grote, Steffi,et al. A high-coverage Neandertal genome from Vindija Cave in Croatia[J]. SCIENCE,2017,358(6363):655-658.
APA	Pruefer, Kay.,de Filippo, Cesare.,Grote, Steffi.,Mafessoni, Fabrizio.,Korlevic, Petra.,...&Paabo, Svante.(2017).A high-coverage Neandertal genome from Vindija Cave in Croatia.SCIENCE,358(6363),655-658.
MLA	Pruefer, Kay,et al."A high-coverage Neandertal genome from Vindija Cave in Croatia".SCIENCE 358.6363(2017):655-658.

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